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栗东芳

栗东芳(lidongfang@genomics.cn),博士,华大股份研发中心感染方向负责人。

研究方向:宏基因组学,病原微生物学,生物信息学等。

现任岗位:华大股份 研发中心 感染方向负责人 

教育背景:华中科技大学 计算机科学与应用 博士

参与项目:

宏基因组方向:

1.靶向宏基因组检测产品PTseq开发

2.成人结直肠癌高精度检测位点关联分析研究

3.儿童呼吸道微生态基因集构建

4.宏基因组检测产品PMseq开发

5.MetaHIT人体肠道微生物基因组计划

微生物基因组方向:

1.2012德国大肠杆菌致病性研究

2.副溶血弧菌基因组群体进化分析

3.结核分枝杆菌耐药位点关联分析研究

4.鼠疫杆菌群体进化研究

论文:

1.Xuebin Wang, Taifu Wang, …, Dongfang Li, Zengquan He. GPMeta: A GPU-accelerated method for ultrarapid pathogen identification from metagenomic sequences. Briefings in Bioinformatics. 2023 March, Volume 24, Issue 2. (IF=13.99,共同通讯作者)

2.Jian Yang, Dongfang Li, Zhenyu Yang et al. Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families. Gut Microbes. 2020 Jan 23:1-17. (IF=7.82,共同第一作者)

3.Dongfang Li, Yinhu Li, Wenkui Dai et al. Intestinal Bacteroides sp. imbalance associated with the occurrence of childhood undernutrition in China. Microbiol. 2019, 2635(10). (IF=4.26,第一作者)

4.Yan Y, Wang H, Li D, Yang X, Wang Z, et al. Two-Step Source Tracing Strategy of Yersinia pestis and Its Historical Epidemiology in a Specific Region. PLoS ONE 2014 9(1): e85374. (IF= 3.057,共同第一作者)

5.Hongtai Zhang, Dongfang Li, Lili Zhao, Joy Fleming et al. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance, Nature Genetics, 2013, Sep. (IF=35.2, 共同第一作者)

6.Yujun Cui, Chang Yu, Yanfeng Yan, Dongfang Li, et al. Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis. PNAS, 2012, Dec. (IF=9.68,共同第一作者)

7.Rohde Holger, Junjie Qin, Yujun Cui, Dongfang Li et al. Open-Source Genomic Analysis of Shiga-Toxin–Producing E. coli O104:H4. The New England Journal of Medicine, 2011; doi:10.1056/NEJMoa1107643 (IF=53.484,共同第一作者)

8.Kehou Pan, Junjie Qin, …, Dongfang Li. Nuclear monoploidy and asexual propagation of nannochloropsis oceanica (eustigmatophyceae) as revealed by its genome sequence1. Journal of Phycology, 2011, 47(6), 1425-1432. (IF=536,共同通讯作者)

9.Hong-Wei Zhou, Dong-Fang Li et al. BIPES, a cost-effective high-throughput method for assessing microbial diversity。ISME J,2011 Apr,5(4):741-749.(IF=7.4,共同第一作者)

10.Junjie Qin, Ruiqiang Li, …, Dongfang Li, et al. A human gut microbial gene catalog established by deep metagenomic sequencing. Nature,4 March 2010,Vol 464:59-65.(IF=36.101)

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