徐晓静(xuxiaojing@genomics.cn),中国科学院大学理学博士,现任杭州华大生命科学研究院副研究员。主要方向为发育与再生、肿瘤异质性与临床耐药及组学新技术研发等。共发表SCI研究论文9篇,国内核心研究论文1篇,相关研究论文发表于Clinical and Translational Medicine、Molecular Oncology、Plant Science等杂志,累计影响因子47.3。其中以第一作者或共同第一作者发表SCI研究论文2篇,以第一申请人或共同申请人申请专利1项,获批软著8项。
研究方向:发育与再生、肿瘤异质性与临床耐药及组学新技术研发等
现任岗位:华大研究院 杭州分院 细胞所 组学技术中心 生物信息副研究员
教育背景:中国科学院大学 基因组学 博士
参与项目:
1.急性淋巴细胞白血病人群大队列单细胞多组学研究
2.百岁长寿老人大人群免疫衰老多组学研究
3.基于单细胞测序的造血干细胞干性维持基因的鉴定与功能研究
论文:
1.Stemness-related genes revealed by single-cell profiling of naïve and stimulated human CD34+ cells from CB and mPB. 2023. Clinical and Translational Medicine. Co-First.
2.Protoplast technology enables the identification of efficient multiplex genome editing tools in Phalaenopsis. 2022. Plant Science: an international journal of experimental plant biology vol. Co First Author.
3.A novel computational method enables RNA editome profiling during human hematopoiesis from scRNA-seq data. 2023. Scientific Reports.
4.Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. 2023. Molecular Oncology.
5.Scaling-up and proteomic analysis reveals photosynthetic and metabolic insights toward prolonged H2 photoproduction in Chlamydomonas hpm91 mutant lacking proton gradient regulation 5 (PGR5). 2022. Photosynthesis Research.
6.Case Report: De novo DDX3X mutation caused intellectual disability in a female with skewed X-chromosome inactivation on the mutant allele. 2022. Frontiers in Genetics.
7.Stereo-cell: spatial enhanced resolution single-cell sequencing with high-density DNA nanoball-patterned arrays. 2024. Science in revision.
专利:
1.徐晓静、董国艺、刘超,一种基于不同来源和体外培养时间的造血干细胞干性维持基因的鉴定方法,202310860439.0,2023.(申请)
软著:
1.徐晓静、孙海汐、欧阳文杰、刘超、顾颖,Barcode Extraction for Cell Identity Tracing [简称:BeCIT]V1.0,2022.
2.徐晓静、孙海汐、董国艺、刘超、顾颖,Estimation of cell origin using SNPs [简称:EcoSNP]V1.0,2022.
3.孙海汐、徐晓静、董国艺、欧阳文杰、刘超、顾颖,Viral Integration Site Detector [简称:VISD]V1.0,2022.
4.陈悦、徐晓静、欧阳文杰、刘超、顾颖,Single-cell RNA data Analysis Wrapper [简称:scWrapper]V1.0,2023.
5.肖韩、孙海汐、徐晓静、王克、华君男、陈悦、李洁、邓子卿、刘心,单细胞Barcode检测软件 [简称:TDSAscBR]V1.0,2024.
6.肖韩、孙海汐、孙凤杰、徐晓静、陈睿颖、邓子卿、刘心,模拟测序数据生成软件 [简称:SRG]V1.0,2024.


