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肖雅洁

肖雅洁(xiaoyajie@genomics.cn),博士,临床科研经理。

研究方向:多组学技术在临床伴随诊断中的应用研究,心血管疾病药物基因组学和群体研究,肿瘤精准诊疗和智能平台研发

现任岗位:华大健康 华大营养 研发部 临床科研经理

教育背景:香港中文大学 内科科学 博士

参与项目:

1.广东省科学技术厅--2018年广东省科技创新战略专项资金(重点领域研发计划)---膀胱癌人工智能一体化精准诊断平台的研发.

2.广东省科学技术厅--2018年广东省科技创新战略专项资金(重点领域研发计划)---医疗数据标注技术体系、通用数据知识库和智能应用平台的建设.

3.华大自主项目--2023年肿瘤精准医学公益项目

论文:

1.Toripalimab plus lenalidomide for central nervous system recurrence in refractory CD5+ diffuse large B-cell lymphoma with MYD88 and CD79B comutation: a case report. Transl Cancer Res. 2024 Feb 29;13(2):1188-1195 (IF 1.7, 共同作者)

2.Prognostic value of neutrophil to lymphocyte ratio and platelet counts during chemotherapy in patients with advanced gastric cancer. Saudi Med J. 2023 Nov;44(11):1104-1112. (IF 2.7, 共同作者)

3.Complete response to first-line osimertinib monotherapy in a complex epidermal growth factor receptor mutant ( L833V / H835L ) lung adenocarcinoma patient: a case report. Anticancer Drugs. 2023 Sep 1;34(8):939-941 (IF2.6, 共同作者)

4.Molecular characteristics of multiple primary pulmonary nodules under a three-dimensional reconstruction model and relevant multi-omics analyses: a case report. Front Oncol. 2023 May 2;13:1064475. (IF 4.5,  #第一作者)

5.Identification of APC mutation as potential predictor for immunotherapy in colorectal cancer. J Immunother Cancer. 2022 Jul 13;2022:6567998. (IF 13.751, *共同通讯)

6.Genomic correlates of programmed cell death ligand 1 (PD-L1) expression in Chinese lung adenocarcinoma patients. Cancer Cell Int.2022 Mar 27;22(1):138.  (IF5.722, #共同一作)

7.A risk score model based on TGF-β pathway-related genes predicts survival,tumor microenvironment and immunotherapy for hepatocellular carcinoma. Funct Integr Genomics. 2022. (IF3.410, #共同一作)

8.Correlation between tumor microenvironment and immune subtypes based on CD8 T cells enhancing personalized therapy of gastric Cancer. J Oncol. 2022 Feb 28;2022:8933167. (IF4.375, #共同一作)

9.Identification and validation of 7-lncRNA signature of epigenetic disorders by Comprehensive epigenetic analysis. Dis Markers. 2022 Feb 2022:5118444. (IF3.434, #共同一作)

10.Expression patterns of glycosylation regulators define tumor microenvironment and immunotherapy in gastric cancer. Front Cell Dev Biol. 2022 Feb 15;10:811075. (IF6.684, 共同作者)

专利:

1.实用新型专利----一种抗肿瘤免疫细胞培养箱.(已授权,证书号19034928)

2.实用新型专利----一种抗肿瘤实验用肿瘤细胞培养装置(已授权,证书号19020534)


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