彭海东（penghaidong@genomics.cn），博士，生化开发高级工程师。曾获得上海市超级博士后，GIM2016国际会议，最佳墙报奖等奖项。
研究方向：生物合成，生物催化，蛋白工程与合成生物学
现任岗位：华大研究院 常州分院 生化所 基因组合成生物学 生化开发高级工程师
教育背景：武汉大学 生物化学与分子生物学 博士
参与项目：
1.基于特征的新型嗜极蛋白挖掘与设计以探索蛋白进化规律，推进产业发展
2.生物法合成DNA
3.氢化酶电催化偶联生物制氢
论文：
1.Peng H, Wang Y, Jiang K, Chen X, Zhang W, Zhang Y,Deng Z and Qu X. A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors. Angew. Chem. Int. Ed. 2021, 60, 5414.
2.Peng H, Wei E, Wang J, Zhang Y, Cheng L, Ma H, Deng Z, Qu X. Deciphering piperidine formation in polyketide-derived indolizidines reveals a thioester reduction, transamination, and unusual imine reduction process. ACS Chemical Biology 2016, 11, 3278.
3.Peng H, Yin Y, Wang Q, Sun C, Zhang Y, Zheng M, Lin Z, Deng Z, Li J and Qu X. A Phytosterol-Based Chemoenzymatic Route to C24-Deoxybile Acids. Nature Communications (2024, in submission)
4.Sun C, Ma B, Li G, Tian W, Yang L, Peng H, Lin Z, Deng Z, Kong X, Qu X. Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines. Angew. Chem. Int. Ed. 2023, 62, e202304994.
5.Tian W, Sun C, Zheng M, Yu M, Zhang Y, Peng H, Zhu D, Harmer J, Deng Z, Chen S, Mobli M, Jia X, Qu X. Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications 2018, 9, 4428.
6.Sun C, Luo Z, Zhang W, Tian W, Peng H, Lin Z, Yan X, Zhang Y, Deng Z, Bostjan K, Jia X, Qu X. Molecular Basis of Regio- and Stereo-Specificity in Biosynthesis of Bacterial Heterodimeric Diketopiperazines. Nature Communications 2020, 11, 6251.
7.Sun C, Peng H, Zhang W, Zheng M, Tian W, Zhang Y, Liu H, Lin Z, Deng Z, Qu X. Production of Heterodimeric Diketopiperazines Employing a Mycobacterium-Based Whole-Cell Biocatalysis System. J. Org. Chem. 2021, 86, 11189.
8.Kandalai S, Li H, Zhang N, Peng H, Zheng Q. The human microbiome and cancer: a diagnostic and therapeutic perspective. Cancer Biology & Therapy 2023, 24, 1.
9.Zhang N, Wu J, Hossain F, Peng H, Li H, Gibson C, Chen M, Zhang H, Gao S, Zheng X, Wang Y, Zhu J, Wang J, Maze I, Zheng Q. Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin. Journal of the American Chemical Society 2024,146,16714.
10.Zhang N, Gao S, Peng H, Wu J, Li H, Gibson C, Zhu J, Zheng Q. Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells. Journal of Proteome Research (2024, DOI: 10.1021/acs.jproteome.4c00379)
