张建国（zhangjg@genomics.cn），博士，研究员，中国科学院大学硕士生导师，曾荣获2003年度中国科学院杰出科技成就集体奖，2009年被深圳市人事局认定为深圳市（国家级）高层次专业人才，参与国家、省市课题19项目，其中主持5项，共发表SCI论文101篇，其中第一或通讯作者（含并列）35篇，参与编写专著两件，获得已授权专利28件。
研究方向：大人群基因组研究；重大慢病队列多组学应用研究
现任岗位：华大基因 智惠医学研究院 主任科学家；华大基因 河北研究院 院长
教育背景：复旦大学 生物信息学 博士
参与项目：
1.罕见病基因组计划
2.百万NIPT大人群基因组研究项目
3.基于多组学方法的帕金森病发病机制研究
4.遗传和环境因素交互作用下神经环路的沉默与早期AD发病
5.阿尔茨海默病遗传机制及生物标记技术研发
6.千种单基因病研究计划
7.西瓜基因组框架图绘制与果实品质基因挖掘
8.印度洋海啸泰国人遗体鉴定项目
9.SARS基因组项目
10.水稻基因组计划
论文：
1.Hankui Liu, Liping Guan, Xi Su, Lijian Zhao, Qing Shu, Jianguo Zhang, 2024, A broken network of susceptibility genes in the monocytes of Crohn’s disease patients. Life Sci Alliance, Published online. (Correspondence author)
2.Chaodong Wang, ..., Jianguo Zhang & Piu Chan, 2024, High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson’s disease. NPJ Parkinsons Dis, 10:134. (Co-orrespondence author)
3.Quanze He, Hankui Liu, ..., Jianguo Zhang, and Ting Wang, 2024, A genome-wide association study of neonatal metabolites. Cell Genom, 4(10):100668. (Co-orrespondence author)
4.Zhongzhong Chen, Yunqian Gao, Lei Lu, Nan Li, Pei Liu, Rui Peng, Lingling Liu, Hefeng Huang, Qihua Fu, Haifa Hong, Jianguo Zhang, Hongyan Wang, 2023, Rare loss-of-function variants reveal threshold and multifactorial inheritance of dextrocardia. Science Bulletin, 68(18):1993-8. (Co-correspondence author)
5.Hankui Liu, Sijie He and Jianguo Zhang, 2021, A bioinformatic study revealed serotonergic neurons are involved in the etiology and therapygenetics of anxiety disorders. Transl Psychiatry, 11:279. (Correspondence author)
6.Roland F.R. Schindler, Chiara Scotton, Jianguo Zhang, ..., Alessandra Ferlini, 2016, POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking. J Clin Invest, 126(1):239-53. (Co-first author)
7.Jianguo Zhang, Pasquale Barbaro, Yiran Guo, ..., John Christodoulou, 2015, Utility of Next Generation Sequencing Technologies for the Efficient Genetic Resolution of Haematological Disorders. Clin Genet, 89(2):163-172.
8.Yongyi Yuan, Jianguo Zhang, ..., Pu Dai, 2014, De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome. Cell Res, 24(11):1370–3. (Co-first author)
9.Shaogui Guo, Jianguo Zhang, ..., Yong Xu, 2013, The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet, 45(1):51-8. (Co-first author)
10.Jun Wang, Jianguo Zhang, Hongkun Zheng, Jun Li, Dongyuan Liu, Heng Li, Ram Samudrala, Jun Yu and Gane Ka-Shu Wong, 2004, Mouse transcriptome: neutral evolution of 'non-coding' complementary DNAs. Nature, 431(7010):757.
