杨卫康（yangweikang@genomics.cn），江南大学发酵工程专业博士，助理研究员，在职华大研究院-常州新一产生物科技有限公司，生物技术副研究员。致力于新型功能蛋白的挖掘、改造和催化机理研究，应用于DNA生物法合成、测序技术、淀粉的酶法功能改造以及益生元合成等邻域。从业以来，杨卫康博士在国际影响力期刊发表SCI论文7篇;申请发明专利9项，授权专利2项。
Yang Weikang(yangweikang@genomics.cn),a Ph.D. in Fermentation Engineering from Jiangnan University, is an assistant researcher and currently working as an associate researcher in biotechnology at BGI. Dr. Yang dedicated to the exploration, modification, and catalytic mechanism research of new functional proteins, applied in DNA biological synthesis, sequencing technology, enzymatic functional modification of starch, and prebiotic synthesis. Since entering the industry, Dr. Yang has published 7 SCI papers in internationally influential journals; Apply for 9 invention patents and grant 2 patents.
研究方向：末端脱氧核苷酸转移酶（TdT）催化酶促法合成DNA是一种具有广泛应用前景的生物技术,有望解决传统化学法只能合成短链<200 nt DNA的缺陷，该技术的成熟将极大刺激DNA数据存储、工程生物学、治疗等领域发展。本课题组由七名博士老师以及一名硕士老师组成。
The enzymatic synthesis of DNA, catalyzed by terminal deoxynucleotidyl transferase (TdT), is a promising biotechnology, and this technology is expected to address the limitation of traditional chemical methods that can only synthesize short-chain DNA of less than 200 nucleotides. The maturation of this technology will greatly stimulate the development of fields, such as DNA data storage technology, synthetic biology, therapeutics and among others. This research group consists of seven PhDs and one Master's degree holder.
现任岗位：华大研究院 常州分院 生物技术副研究员
教育背景：江南大学 发酵工程 博士
参与项目：
1.生物法oligo合成
2.蛋白开发平台
论文：
1.Weikang Yang, Lufei Sheng, Lingqia Su, Sheng Chen, Jing Wu. (2021). Directed mutation of two key amino acid residues alters the product structure of the new 4,6-alpha-glucanotransferase from Bacillus sporothermodurans. Journal of Agricultural and Food Chemistry, 69, 14680-14688
2.Weikang Yang, Lufei Sheng, Sheng Chen, Lei Wang, Lingqia Su, Jing Wu. (2022). Characterization of a new 4,6-α-glucanotransferase from Limosilactobacillus fermentum NCC 3057 with ability of synthesizing low molecular mass isomalto-/maltopolysaccharide. Food Bioscience, 46, 101514.
3.Weikang Yang, Lingqia Su, Lei Wang, Jing Wu, Sheng Chen. (2022). Adjusting the α(1-6) bond proportion of isomalto-/maltopolysaccharide by regulating the hydrophobicity of the acceptor site of 4,6-α-glucanotransferase. Biochemical Engineering Journal, 108427.
4.Weikang Yang, Lingqia Su, Lei Wang, Jing Wu, Sheng Chen. (2022). Alpha-glycosyltransferase from the glycoside hydrolase family synthesizes α(1-6)-linked products from starch: Features and synthesis pathways of the products. Trends in Food Science & Technology, 128, 160-172.
5.Beibei Wei, Wei Xia, Lei Wang, Xuewei Jin, Weikang Yang, Deming Rao, Sheng Chen, Jing Wu. (2021). Diverse prebiotic effects of isomaltodextrins with different glycosidic linkages and molecular weights on human gut bacteria in vitro. Carbohydrate Polymers, 118986.
6.DemingRao, LeiWang, RuntianHuo, LingqiaSu, ZhiyongGuo, WeikangYang, BeibeiWei, XiumeiTao, ShengChen, JingWu. (2022). Trehalose promotes high-level heterologous expression of 4,6-α-glucanotransferase GtfR2 in Escherichia coli and mechanistic analysis. International Journal of Biological Macromolecules, 315-323.
