谢国云（xieguoyun@genomics.cn），深圳华大基因股份有限公司智惠医学研究院，基因组学助理研究员。在癌症多组学、单细胞以及空间组学研究领域有10余年研究经验。发表科研论文7篇，授权/受理发明专利2项，软件著作权8件，主持或参与国家、省、市各级科研经费项目5项。
研究方向：癌症多组学大数据研究；基于单细胞和空间转录组学研究肿瘤、免疫、血管的异质性及其的相互作用关系；基于AI基于图像和时空数据构建肿瘤血管分型的人工智能诊断模型
现任岗位：华大股份 智惠医学研究院 专项科学家
教育背景：哈尔滨医科大学 生物信息学 本科
参与项目：
1.肺癌多组学和基因编辑研究
2.脑胶质瘤时空组学研究
3.癌症大数据集成及应用平台建设
4.基于图像和时空数据构建肿瘤血管分型的人工智能诊断模型
论文：
1.Ma*, B. Kang*, S. Li*, G. Xie*, J. Bi, F. Li, G. An, B. Liu, J. Li, Y. Shen, X. Xu, H. Yang, Y. Yang, Y. Gu, N. Wu, CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma, Mol Ther 30(11) (2022) 3341-3357.
2.Liang, F. Li, S. Qiao, X. Zhou, G. Xie, X. Zhao, Y. Zhang, K. Wu, Whole-genome sequencing of cell-free DNA yields genome-wide read distribution patterns to track tissue of origin in cancer patients, Clin Transl Med 10(6) (2020) e177.
3.Zhang*, B. Kang*, G. Xie*, S. Li*, Y. Gu*, Y. Shen*, X. Zhao*, Y. Ma, F. Li, J. Si, J. Wang, J. Chen, H. Yang, X. Xu, Y. Yang, Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer, Cancer Lett 442 (2019) 53-67.
4.Wang, H. Liang, C. Lin, F. Li, G. Xie, S. Qiao, X. Shi, J. Deng, X. Zhao, K. Wu, X. Zhang, Molecular Subtyping and Prognostic Assessment Based on Tumor Mutation Burden in Patients with Lung Adenocarcinomas, Int J Mol Sci 20(17) (2019).
5.Wu, X. Zhang, F. Li, D. Xiao, Y. Hou, S. Zhu, D. Liu, X. Ye, M. Ye, J. Yang, L. Shao, H. Pan, N. Lu, Y. Yu, L. Liu, J. Li, L. Huang, H. Tang, Q. Deng, Y. Zheng, L. Peng, G. Liu, X. Gu, P. He, Y. Gu, W. Lin, H. He, G. Xie, H. Liang, N. An, H. Wang, M. Teixeira, J. Vieira, W. Liang, X. Zhao, Z. Peng, F. Mu, X. Zhang, X. Xu, H. Yang, K. Kristiansen, J. Wang, N. Zhong, J. Wang, Q. Pan-Hammarstrom, J. He, Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas, Nat Commun 6 (2015) 10131.
6.Wu, X. Zhang, Z. Zhao, L. Wang, B. Li, G. Li, M. Dean, Q. Yu, Y. Wang, X. Lin, W. Rao, Z. Mei, Y. Li, R. Jiang, H. Yang, F. Li, G. Xie, L. Xu, K. Wu, J. Zhang, J. Chen, T. Wang, K. Kristiansen, X. Zhang, Y. Li, H. Yang, J. Wang, Y. Hou, X. Xu, Full-length single-cell RNA-seq applied to a viral human cancer: applications to HPV expression and splicing analysis in HeLa S3 cells, Gigascience 4 (2015) 51.
7.Y. Hou, K. Wu, X. Shi, F. Li, L. Song, H. Wu, M. Dean, G. Li, S. Tsang, R. Jiang, X. Zhang, B. Li, G. Liu, N. Bedekar, N. Lu, G. Xie, H. Liang, L. Chang, T. Wang, J. Chen, Y. Li, X. Zhang, H. Yang, X. Xu, L. Wang, J. Wang, Comparison of variations detection between whole-genome amplification methods used in single-cell resequencing, Gigascience 4 (2015) 37.
Google scholar 链接：https://scholar.google.com/citations?hl=zh-CN&user=QWyf3DIAAAAJ
