覃友文（qinyouwen@genomics.cn），累计发表10篇人体微生物组研究论文；独立一作发表《Nature Genetics 》文章1篇(PMID: 35115689)。获批2项发明专利，其中1项为第一发明人。在结直肠癌方向，与中山大学肿瘤防治中心丁培荣教授合作发表一篇《Nature Communications》论文（38649355）; 与领域大牛于君教授合作发表一篇《Gut》论文（PMID: 26408641）。在胃癌研究方向，与香港大学Leung W. K. 教授合作发表一篇《Scientific report》论文(PMID: 28322295)。与上海交通大学房静远教授的一篇合作文章在《Nature Microbiology》审稿中。当前的研究专注于大规模人群的人体微生物组研究，以及人体微生态与消化系统肿瘤发生发展、筛查诊断和治疗预后的研究。副研究员职称，获评深圳市海外高层次人才。
研究方向：消化系统肿瘤（结直肠癌、胃癌）、人体微生态、多组学
现任岗位：华大股份 智惠医学研究院 专项科学家
教育背景：澳大利亚墨尔本大学 基因组学 博士
参与项目：
1.千万微生态—肠道和口腔菌群与消化系统肿瘤的研究
2.千万微生态—肠道和口腔菌群与重金属暴露的研究
3.超级工程--结直肠癌多组学研究
论文：
大人群多组学研究文章
1.Youwen Qin, Aki S Havulinna, Yang Liu, Pekka Jousilahti, Scott C Ritchie, Alex Tokolyi, Jon G Sanders, Liisa Valsta, Marta Brozynska, Qiyun Zhu, Anupriya Tripathi, Yoshiki Vazquez-Baeza, Rohit Loomba, Susan Cheng, Mohit Jain, Teemu Niiranen, Leo Lahti, Rob Knight, Veikko Salomaa, Michael Inouye#, Guillaume Meric#. Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. Nature Genetics, (2022). (CGM华人基因组学在线沙龙https://www.bilibili.com/video/BV12u411e7QZ/ )
2.Heikki V Sarin*, Juha J Hulmi*, Youwen Qin*, et al. Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins. Metabolites, (2022).
3.Youwen Qin, Guillaume Méric, Tao Long, Jeramie D. Watrous, Stephen Burgess, Aki S. Havulinna, Scott C. Ritchie, Marta Brożyńska, Pekka Jousilahti, Markus Perola, Leo Lahti, Teemu Niiranen, Susan Cheng, Veikko Salomaa, Mohit Jain, Michael Inouye. Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases. medRxiv, doi: https://doi.org/10.1101/2020.08.01.20166413, (2020). (1st round revision in Nature Communications)
消化道肿瘤研究文章
4.Youwen Qin*#, Xin Tong*, Wei-Jian Mei*, Yanshuang Cheng, Yuanqiang Zou, Kai Han, Jiehai Yu, Zhuye Jie, Tao Zhang, Shida Zhu, Xin Jin, Jian Wang, Huanming Yang, Xun Xu, Huanzi Zhong, Liang Xiao, Pei-Rong Ding#. Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer. Nature Communications 15, 3396 (2024). https://doi.org/10.1038/s41467-024-47523-x.
5.Jun Yu, et al. [Youwen Qin 6th of 39 authors] Metagenomic analysis of fecal microbiome as a tool towards identification of targeted non-invasive biomarkers for colorectal cancer. Gut, (2017).
6.Tung Hiu Li, Youwen Qin, Pak Chung Sham, K.S. Lau, Kent-Man Chu & Wai K. Leung. Alterations in gastric microbiota after Pylori eradication and in different histological stages of gastric carcinogenesis. Scientific Report, (2017).
人体微生物与代谢疾病的研究文章
7.Juergen Graessler*, Youwen Qin*, Huanzi Zhong*, et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters. The Pharmacogenomics Journal, (2013).
8.Junjie Qin, et al. [Youwen Qin 15th of 46 authors] A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature, (2012).
结核杆菌基因组和耐药性的研究文章
9.M Silcocks, X Chang, NT Thuong Thuong, Y Qin, et al. Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam. Microbiology Spectrum, (2023).
10.TM Walker, P Miotto, CU Köser, PW Fowler, J Knaggs…CRyPTIC Consortium… et al. The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis. The Lancet Microbe, (2022).
Google scholar 链接：https://scholar.google.com.hk/citations?user=hpAOpR8AAAAJ&hl=en
ORCID链接：https://orcid.org/0000-0003-3956-4711
