缪海涛(miaohaitao@genomics.cn),华大智造生化开发中级工程师。博士,主要从事基因测序仪的生物化学技术开发以及相关测序试剂的开发。
研究方向:生物化学、测序技术开发、测序试剂开发
现任岗位:华大智造 高通量测序研发中心 测序新平台研发部 生化开发中级工程师
教育背景:香港科技大学 生命科学 博士
参与项目:
1.DNBSEQ-G99测序试剂研发
2.超快速生化技术开发
3.RMB(Revolution of MGI's Biochemistry)
论文:
1.Xu N, You Y, Liu C, Maxim Balasov, Geng Y, Fung C, Miao H, Tian H, Shi X, Choy T, Rahman Ud DIN, Zhou B, Katarina Akhmetova, Yang H, Igor Chesnokov, Zhu G. Structural Basis of DNA Replication Origin Recognition by Human Orc6 Protein Binding with DNA. Nucleic Acids Res.
2.Geng Y, Liu C, Cai Q, Miao H, Shi X, Xu N, You Y, Fung CP, Din RU, Zhou B, Zhu G. Crystal structure of parallel G-quadruplex formed by the two-repeat ALS and FTD related GGGGCC sequence. Nature Communications.
3.Liu C, Geng Y, Miao H, Shi X, You Y, Xu N, Zhou B, Zhu G. G-quadruplex structures formed by human telomeric DNA and C9orf72 hexanucleotide repeats. Biophys Rev. 2019 Jun;11(3):389-393.
4.Geng Y, Liu C, Zhou B, Cai Q, Miao H, Shi X, Xu N, You Y, Fung CP, Din RU, Zhu G. The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA. Nucleic Acids Res. 2019 Jun 4;47(10):5395-5404.
5.Liu C, Zhou B, Geng Y, Yan Tam D, Feng R, Miao H, Xu N, Shi X, You Y, Hong Y, Tang BZ, Kwan Lo P, Kuryavyi V, Zhu G. A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution. Chem Sci. 2018 Oct 4;10(1):218-226.
6.Zhou B, Geng Y, Liu C, Miao H, Ren Y, Xu N, Shi X, You Y, Lee T, Zhu G. Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence. Sci Rep. 2018 Feb 5;8(1):2366.


