侯桂雪（houguixue@genomics.cn），副研究员，2016年毕业于中科院北京基因组研究所，获得博士学位。2016-2019年在华大-哈工大联合开展博士后工作，深圳市高层次人才。目前担任华大质谱方向技术导师，东北林业大学硕士生导师。参与国家重点专项、中国博士后基金、973计划和863计划等多项科研项目。研发方向为质谱相关技术开发与应用，主导了多项蛋白质组与代谢组相关的前沿技术开发及科研应用项目。
研究方向：蛋白质组及代谢组技术开发与应用、疾病多组学研究
现任岗位：华大股份 质谱业务部 质谱组学研究 部门副总监
教育背景：中国科学院大学 北京基因组研究所 博士
参与项目：
1.国家重点专项“生命科学仪器中的关键配套试剂耗材研发与量产应用" 课题骨干
2.主导高通量靶向代谢定量试剂盒研发，并应用于多种疾病队列多组学研究项目,如皮肤类疾病、心脑血管疾病等
3.主导基于高分辨质谱的蛋白质组定量技术平台搭建，并应用于蛋白标志物的发现与验证
4.围绕妊娠并发症及新生儿遗传代谢类疾病，开展基因组+蛋白质组+代谢组等跨组学研究
5.肿瘤相关的空间蛋白质组与单细胞蛋白质组技术开发及应用
论文：
1.Zhang W, Dai J, Hou G, Liu H, Zheng S, Wang X, Lin Q, Zhang Y, Lu M, Gong Y, Xiang Z, Yu Y, Hu Y. SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation. Mol Cell. 2023 Dec 7;83(23):4352-4369.e8. doi: 10.1016/j.molcel.2023.10.042
2.Chen C#, Hou G#, Zeng C, Ren Y, Chen X, Peng C. Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis. Theranostics. 2021 Jan 1;11(2):754-767. doi: 10.7150/thno.51154
3.Liu H, Zheng S, Hou G, Dai J, Zhao Y, Yang F, Xiang Z, Zhang W, Wang X, Gong Y, Li L, Zhang N, Hu Y. AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis. Cell Death Differ. 2024 Nov 13. doi: 10.1038/s41418-024-01414-2
4.He M#, Hou G#, Liu M, Peng Z, Guo H, Wang Y, Sui J, Liu H, Yin X, Zhang M, Chen Z, Rensen PCN, Lin L, Wang Y, Shi B. Lipidomic studies revealing serological markers associated with the occurrence of retinopathy in type 2 diabetes. J Transl Med. 2024 May 13;22(1):448. doi: 10.1186/s12967-024-05274-9
5.Jian X#, Hou G#, Li L, Diao Z, Wu Y, Wang J, Xie L, Peng C, Lin L, Li J. Identification of pyruvic and maleic acid as potential markers for disease activity and prognosis in chronic urticaria. J Allergy Clin Immunol. 2024 Aug;154(2):412-423. doi: 10.1016/j.jaci.2024.01.032
6.Xiang Z, Hou G, Zheng S, Lu M, Li T, Lin Q, Liu H, Wang X, Guan T, Wei Y, Zhang W, Zhang Y, Liu C, Li L, Lei QY, Hu Y. ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2403038121. doi: 10.1073/pnas.2403038121
7.Hou G#, Gao Y#, Poon LC#, Ren Y, Zeng C, Wen B, Syngelaki A, Lin L, Zi J, Su F, Xie W, Chen F, Nicolaides KH. Maternal plasma diacylglycerols and triacylglycerols in the prediction of gestational diabetes mellitus. BJOG. 2023 Feb;130(3):247-256. doi: 10.1111/1471-0528.17297
8.Li Y#, Hou G#, Zhou H, Wang Y, Tun HM, Zhu A, Zhao J, Xiao F, Lin S, Liu D, Zhou D, Mai L, Zhang L, Zhang Z, Kuang L, Guan J, Chen Q, Wen L, Zhang Y, Zhuo J, Li F, Zhuang Z, Chen Z, Luo L, Liu D, Chen C, Gan M, Zhong N, Zhao J, Ren Y, Xu Y. Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery. Signal Transduct Target Ther. 2021 Apr 15;6(1):155. doi: 10.1038/s41392-021-00508-4
9.Zhou X#, Hou G#, Wang X, Peng Z, Yin X, Yang J, Wang S, He Y, Wang Y, Sui J, Qiang W, Guo H, Wang Y, Lin L, Shi B, He M. Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. 2024 Dec 18;23(1):439. doi: 10.1186/s12933-024-02535-1
10.Li J, Li L, Liu R, Zhu L, Zhou B, Xiao Y, Hou G*, Lin L*, Chen X*, Peng C*. Integrative lipidomic features identify plasma lipid signatures in chronic urticaria. Front Immunol. 2022 Jul 28;13:933312. doi: 10.3389/fimmu.2022.933312
