韩磊（hanlei2@genomics.cn），毕业于香港大学医学院并获得神经生物学博士学位。杭州华大生命科学研究院脑科学方向主任科学家，副研究员，人脑疾病项目组负责人。研究方向是通过细胞多组学数据研究神经疾病的细胞和分子层面的病理机制。曾利用华大自主研发的单细胞测序技术构建了世界上首个非人灵长类全身器官细胞图谱，该研究成果发表在Nature，被评为“2022年中国医药生物技术十大进展”以及“2022年中国十大医学科技新闻”。目前研究结果已在Nature，Science，Cell，Nature Communications，Journal of Physiology，Neuropharmacology等杂志发表论文。研究获得国家自然科学基金，科技部脑科学与类脑研究重大项目等资助。
研究方向：利用细胞多组学技术解析脑功能和脑疾病的机制
现任岗位：华大研究院 杭州分院 细胞所 主任科学家
教育背景：香港大学 神经生物学 博士
参与项目：
1.非人灵长类全身器官细胞图谱
2.人脑阿尔茨海默症海马细胞空间图谱
3.小鼠全脑细胞和分子空间图谱
论文：
1.Lei Han*; Xiaoyu Wei*; Chuanyu Liu*; Giacomo Volpe*; Zhenkun Zhuang*; Xuanxuan Zou*; Zhifeng Wang*; Taotao Pan; Yue Yuan; Xiao Zhang; Peng Fan; Pengcheng Guo; Yiwei Lai; Ying Lei; Xingyuan Liu; Feng Yu; Shuncheng Shangguan; Guangyao Lai; Qiuting Deng; Ya Liu; Liang Wu; Quan Shi; Hao Yu; Yunting Huang; Mengnan Cheng; Jiangshan Xu; Yang Liu; Mingyue Wang; Chunqing Wang; Yuanhang Zhang; Duo Xie; Yunzhi Yang; Yeya Yu; Huiwen Zheng; Yanrong Wei; Fubaoqian Huang; Junjie Lei; Waidong Huang; Zhiyong Zhu; Haorong Lu; Bo Wang; Xiaofeng Wei; Fengzhen Chen; Tao Yang; Wensi Du; Jing Chen; Shibo Xu; Juan An; Carl Ward; Zongren Wang; Zhong Pei; Chi-Wai Wong; Xiaolei Liu; Huafeng Zhang; Mingyuan Liu; Baoming Qin; Axel Schambach; Joan Isern; Liqiang Feng; Yan Liu; Xiangyu Guo; Zhen Liu; Qiang Sun; Patrick H. Maxwell; Nick Barker; Pura Muñoz-Cánoves; Ying Gu; Jan Mulder; Mathias Uhlen; Tao Tan; Shiping Liu; Huanming Yang; Jian Wang; Yong Hou; Xun Xu; Miguel A. Esteban; Longqi Liu ; Cell transcriptomic atlas of the non-human primate Macaca fascicularis, Nature, 2022, 604(7907): 723-731 ( *:共同第一作者 ).
2.Lei Han*; Kenneth Lap-Kei Wu*; Pui-Yi Kwan; Oscar Wing-Ho Chua; Daisy Kwok-Yan Shum; Ying-Shing Chan; 5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function, Journal of Physiology-London, 2021, 599(1): 253-267 ( *:共同第一作者 ) .
3.Yanrong Wei, Junjie Lei, Yujie Peng, Huizhong Chang, Ting Luo, Yuanchun Tang, Lifang Wang, Huiying Wen, Giacomo Volpe, Longqi Liu#,Lei Han#. Expression characteristics and potential function of non-coding RNA in mouse cortical cells. Frontiers in Molecular Neuroscience, 2024, doi: 10.3389/fnmol.2024.1365978 ( #:共同通讯作者 ).
4.Quyuan Tao, Yiheng Xu, Youzhe He, Ting Luo, Xiaoming Li#,Lei Han#. Benchmarking Mapping Algorithms for Cell Type Annotating in Mouse Brain by Integrating Single-Nucleus RNA-seq and Stereo-seq Data. Briefings in Bioinformatics, 2024, doi: 10.1093/bib/bbae250 ( #:共同通讯作者 ).
5.Huiying Wen, Youzhe He, Yuanchun Tang, Langjian Zhu, Quyuan Tao, Bufan Jin, Ting Luo, Yujie Peng, Yanrong Wei, Junjie Lei, Lifang Wang, Fan Wang, Fei Ling#, Yue Gao#, Lei Han#. Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex. Brain Pathology, 2024, doi: 10.1111/bpa.13318, ( #:共同通讯作者 ).
6.Lei Han*; et al., Single-cell spatial transcriptomic atlas of the whole mouse brain. Neuron, 2024 ( *:共同第一作者 ) (Accepted).
