高玥（gaoyue3@genomics.cn），杭州华大生命科学研究院生物信息副研究员，浙江大学博士后，毕业于南方医科大学生物信息专业。现主要从事脑衰老、脑疾病、脑图谱的研究。
研究方向：系统生物学、生物信息学
现任岗位：华大研究院 杭州分院 细胞所脑科学中心 生物信息副研究员
教育背景：南方医科大学 生物信息学 博士
参与项目：
1.国家自然基金项目82071503，通过高通量构建精神分裂症分子网络阐明免疫激活导致发病的分子机理
2.国家自然科学基金面上项目，31771434，系统绘制人类胚胎脑组织lncRNA-蛋白相互作用二元网络图谱
3.广东省科技计划项目，2017B020227010，精神分裂症精准分子分型和个性化诊疗模式及其临床应用
4.广东省基础与应用基础研究研究基金项目：区域联合基金-重点项目，2019B1515120080，通过对自闭症核心家系的单细胞组学研究阐明自闭症发病分子机理
论文:
1.Wen H#, He Y#, Tang Y, Zhu L, Tao Q, Jin B, Luo T, Peng Y, Wei Y, Lei J, Wang L, Wang F, Ling F, Gao Y*, Han L*. Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex. Brain Pathol. 2024 Nov 4:e13318.
2.Wang, J.#, Gao, Y.#, Xiao, L.#, Lin, Y., Huang, L., Chen, J., Liang, G., Li, W., Yi, W., Lao, J., Zhang, B., Gao, T. M., Zhong, M., & Yang, X. (2023). Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1-/- mice. iScience, 26(8), 107476.
3.Gao, Y., Li, Y., Li, S., Liang, X., Ren, Z., Yang, X., Zhang, B., Hu, Y., and Yang, X. (2021). Systematic discovery of signaling pathways linking immune activation to schizophrenia. iScience 24, 103209.
4.Huang, L.#, Wang, J.#, Liang, G.#, Gao, Y.#, Jin, S.Y., Hu, J., Yang, X., Lao, J., Chen, J., Luo, Z.C., et al. (2021). Upregulated NMDAR-mediated GABAergic transmission underlies autistic-like deficits in Htr3a knockout mice. Theranostics 11, 9296-9310.
5.Fan, C.#, Gao, Y.#, Liang, G., Huang, L., Wang, J., Yang, X., Shi, Y., Drager, U.C., Zhong, M., Gao, T.M., et al. (2020). Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy. Molecular autism 11, 13.
6.Ren Z, Gao Y, Gao Y, Liang G, Chen Q, Jiang S, Yang X, Fan C, Wang H, Wang J, Shi YW, Xiao C, Zhong M, Yang X. (2021). Distinct placental molecular processes associated with early-onset and late-onset preeclampsia. Theranostics, 11(10), 5028–5044.
7.Hu Y, Comjean A, Rodiger J, Liu Y, Gao Y, Chung V, Zirin J, Perrimon N, Mohr SE. (2021). FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update. Nucleic Acids Res. 49(D1) D908-D915.
8.Hu, Y., Tattikota, S.G., Liu, Y., Comjean, A., Gao, Y., Forman, C., Kim, G., Rodiger, J., Papatheodorou, I., Dos Santos, G., et al. (2021). DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species. Computational and structural biotechnology journal 19, 2018-2026.
9.Hong-Wen Tang #, Kerstin Spirohn #, Yanhui Hu, Tong Hao, István A Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H Wan, Joel S Bader, Dawit Balcha, Wenting Bian, Benjamin W Booth 8, Atina G Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P Roth, Jan Tavernier, Michael A Calderwood, David E Hill, Susan E Celniker, Marc Vidal, Norbert Perrimon, Stephanie E Mohr. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Nat Commun. 2023 Apr 15;14(1):2162.
专利：
1.第四作者，一种自闭症小鼠模型的构建方法，ZL201911016844.4
2.第二作者，一种精神分裂症基因-基因互作网络及其构建方法，ZL201911021952.0
3.第三作者，一种利用蛋白质互作网络构建自闭症动物模型的方法，ZL201911106432.X
4.第三作者，一种精神分裂症异常基因-代谢调控网络的构建方法及应用，专利号：ZL202210739157.0
