方超（fangchao@genomics.cn），本科毕业于中山大学，后于丹麦哥本哈根大学获分子生物学博士，主攻生信工具开发与应用创新。2013年加入华大基因，从事宏基因组学技术开发与生物信息学方法学构建。了解生命科学领域的研究和产业发展方向，熟悉大规模基因组、生物信息学、人工智能应用研究的发展与应用，有良好的团队组建和管理运营能力。
熟悉二、三代测序等高通量平台的技术特点和各种下游应用的数据特征、分析思路、算法策略，包括全新参考基因组构建、变异检测、微生物生态学以及微生物组与宿主的互作等，研究领域涉及人体共生微生物、肿瘤微环境、病原多组学、深度学习等。多次在国内外学术会议上做专题报告，发表文献二十余篇。其中第一作者（共一）5篇，参与主刊一篇，平均影响因子在5分以上，h指数15，总引用数超千次。参与了生物信息软件、流程开发，获得专利3项，软件著作权1项，深圳市孔雀计划基金结题一项。
研究方向：目前聚焦人工智能全栈技术框架与技术热点，负责医学染方向AI转化应用的学(学生培养）、研（技术突破）、产（产品落地）一体协同，负责基于PMSEQ的智能体产品的研发与临床场景落地，课题组需求方向包括1）真实世界大规模临床医学资料数据治理；2）病原基因组序列基座开发；3）病原检测下游任务微调；4）临床辅助诊疗智能体搭建。
现任岗位：华大研究院 北京分院 病原所 项目负责人
教育背景：哥本哈根大学 分子生物学 博士
参与项目：
1.MEER深渊微生物. (Cell. Microbial ecosystem and ecological driving forces in the deepest ocean sediments)
2.stLFR长扩增子算法开发. (Cell Rep Methods. High-resolution single-molecule long-fragment rRNA gene amplicon sequencing of bacterial and eukaryotic microbial communities. )
3.肿瘤微生物标志物（Front Oncol. Distinct Functional Metagenomic Markers Predict the Responsiveness to Anti-PD-1 Therapy in Chinese Non-Small Cell Lung Cancer Patients.）
论文:
1. Xiao X, Zhao W, Song Z, Qi Q, Wang B, Zhu J, Lin J, Wang J, Hu A, Huang S et al: Microbial ecosystems and ecological driving forces in the deepest ocean sediments. Cell 2025, 188(5):1363-1377.e1369.
2. Liang Y, Huang Z, Fan S, Li C, Huang L, Huang C, Hutchins AP, Fang C, Zhang X, Pericolini E: Highlight signatures of vaginal microbiota and metabolome contributed to the occurrence and recurrence of vulvovaginal candidiasis. Microbiology Spectrum 2024, 12(12):e0152124.
3. Qi F, Fan S, Fang C, Ge L, Lyu J, Huang Z, Zhao S, Zou Y, Huang L, Liu X et al: Orally administrated Lactobacillus gasseri TM13 and Lactobacillus crispatus LG55 can restore the vaginal health of patients recovering from bacterial vaginosis. Frontiers in Immunology 2023, 14.
4. Fang C, Sun X, Fan F, Zhang X, Wang O, Zheng H, Peng Z, Luo X, Chen A, Zhang W et al: High-resolution single-molecule long-fragment rRNA gene amplicon sequencing of bacterial and eukaryotic microbial communities. Cell Reports Methods 2023, 3(3):100437.
5. Zhu Y, Fang C, Shi Y, Shan Y, Liu X, Liang Y, Huang L, Liu X, Liu C, Zhao Y et al: Candida albicans Multilocus Sequence Typing Clade I Contributes to the Clinical Phenotype of Vulvovaginal Candidiasis Patients. Frontiers in Medicine 2022, 9:837536.
6. Zhao F, Wang C, Song S, Fang C, Zhou G, Li C, Kristiansen K: Casein and red meat proteins differentially affect the composition of the gut microbiota in weaning rats. Food Chemistry 2022, 397:133769.
7. Zajc J, Černoša A, Sun X, Fang C, Gunde-Cimerman N, Song Z, Gostinčar C: From Glaciers to Refrigerators: the Population Genomics and Biocontrol Potential of the Black Yeast Aureobasidium subglaciale. Microbiology Spectrum 2022, 10(4):e01455-01422.
8. Xu L, Ma Y, Fang C, Peng Z, Gao F, Moll JM, Qin S, Yu Q, Hou Y, Kristiansen K et al: Genomic and microbial factors affect the prognosis of anti-pd-1 immunotherapy in nasopharyngeal carcinoma. Front Oncol 2022, 12:953884.
9. Fang C, Fang W, Xu L, Gao F, Hou Y, Zou H, Ma Y, Moll JM, Yang Y, Wang D et al: Distinct Functional Metagenomic Markers Predict the Responsiveness to Anti-PD-1 Therapy in Chinese Non-Small Cell Lung Cancer Patients. Front Oncol 2022, 12:837525.
10. Zhang X, Zhong H, Li Y, Shi Z, Ren H, Zhang Z, Zhou X, Tang S, Han X, Lin Y et al: Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. Nature Aging 2021, 1(1):87-100.
11. Sun X, Hu YH, Wang J, Fang C, Li J, Han M, Wei X, Zheng H, Luo X, Jia Y et al: Efficient and stable metabarcoding sequencing data using a DNBSEQ-G400 sequencer validated by comprehensive community analyses. GigaByte 2021, 2021:gigabyte16.
12. Cernosa A, Sun X, Gostincar C, Fang C, Gunde-Cimerman N, Song Z: Virulence Traits and Population Genomics of the Black Yeast Aureobasidium melanogenum. J Fungi (Basel) 2021, 7(8).
13. Zou H, Wang D, Ren H, Cai K, Chen P, Fang C, Shi Z, Zhang P, Wang J, Yang H et al: Effect of Caloric Restriction on BMI, Gut Microbiota, and Blood Amino Acid Levels in Non-Obese Adults. Nutrients 2020, 12(3).
14. Zhong H, Ren H, Lu Y, Fang C, Hou G, Yang Z, Chen B, Yang F, Zhao Y, Shi Z: Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics. EBioMedicine 2019, 47:373-383.
15. Zhong H, Penders J, Shi Z, Ren H, Cai K, Fang C, Ding Q, Thijs C, Blaak EE, Stehouwer CD: Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children. Microbiome 2019, 7(1):2.
16. Sun X, Gostincar C, Fang C, Zajc J, Hou Y, Song Z, Gunde-Cimerman N: Genomic Evidence of Recombination in the Basidiomycete Wallemia mellicola. Genes (Basel) 2019, 10(6):427.
17. Gostincar C, Sun X, Zajc J, Zalar P, Turk M, Zupancic J, Tang Y, Fang C, Luo Y, Song Z: On generalists and specialists among halotolerant fungi. Studia Universitatis Babes-Bolyai, Biologia 2019, 64(1).
18. Gostinčar C, Sun X, Zajc J, Zalar P, Tang Y, Fang C, Luo Y, Song Z, Gunde-Cimerman N: The maverick fungal genus Wallemia-from halotolerant W. mellicola to halophilic and chaotolerant W. ichthyophaga. Studia Universitatis Babes-Bolyai, Biologia 2019, 64(1).
19. Gostinčar C, Sun X, Zajc J, Fang C, Hou Y, Luo Y, Gunde-Cimerman N, Song Z: Population genomics of an obligately halophilic basidiomycete Wallemia ichthyophaga. Frontiers in microbiology 2019, 10.
20. Fang C, Zhong H, Lin Y, Chen B, Han M, Ren H, Lu H, Luber JM, Xia M, Li W et al: Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing. Gigascience 2018, 7(3):1-8.
21. Zhong H, Fang C, Fan Y, Lu Y, Wen B, Ren H, Hou G, Yang F, Xie H, Jie Z et al: Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic, and type 2 diabetic individuals. Gigascience 2017, 6(7):1-12.
22. Sun Y, Guo C-Y, Wang D-D, Li XF, Xiao L, Zhang X, You X, Shi Q, Hu G-J, Fang C: Transcriptome analysis reveals the molecular mechanisms underlying growth superiority in a novel grouper hybrid (Epinephelus fuscogutatus♀× E. lanceolatus♂). BMC genetics 2016, 17(1):1-10.
Google Scholar profile: https://scholar.google.com/citations?user=AOPJMJIAAAAJ
项目仓库(公开部分）：https://github.com/BioChaoGroup
个人公开项目：https://github.com/biociao
个人公开视频课：https://space.bilibili.com/81748
