程莹莹(chengyingying@genomics.cn),博士,硕士生导师,于新加坡南洋理工大学完成博士后研究。深圳市海外高层次人才,深圳市盐田区梧桐凤凰人才,主持完成国家自然科学基金青年基金和深圳市科创委基础研究面上项目,参与各级纵向课题项目多项,发表SCI论文十余篇,参与国家专利5项。现任深圳华大法医科技有限公司专项负责人,主要负责高通量测序技术的法医学应用系统研发,以及前沿技术孵化,主导完成法医学DNA检测技术及产品研发项目多项,为一线法医学工作者提供完整解决方案。
研究方向:
1.法医物证学核酸鉴定,包括个体识别、亲缘鉴定等技术孵化及检测产品研发;
2.细菌群体互作,包括细菌耐药、生物被膜、多组学研究等;
3.植物病理学,包括植物与微生物互作,致病因子合成机制等。
现任岗位:华大鉴正 研发中心 技术研发 专项负责人
教育背景:华南农业大学 植物病理学 博士
参与项目:
1.国家自然科学基金:铜绿假单胞菌与嗜麦芽寡养单胞菌在共同感染中的互作机制研究,21万,主持;
2.深圳市科创委:绿脓杆菌与嗜麦芽窄食单胞菌分子流行病学及其在共感染中的互作机制研究,10万,主持;
3.华大鉴正:实验室技术一体化系统开发,165万,主持;
4.华大鉴正:线粒体全基因组检测试剂盒(短片段)研发,37万,主持;
5.华大鉴正:配套试剂盒的自动化流程开发,13万,主持;
6.华大鉴正:E25的法医学应用开发,26万,主持;
7.华大鉴正:系谱推断项目,14万,主持;
8.华大鉴正:全自动化建库技术开发,45万,主持;
9.华大鉴正:动植物基因身份证,10万,参与;
10.华大鉴正:基于CYCLONE测序技术的连锁遗传标记方法探索,13万,参与;
论文:
1.Yingying Cheng, Joey Kuok Hoong Yam, Zhao Cai, et al. 2019. Population dynamics and transcrip tomic responses of Pseudomonas aeruginosa in a complex laboratory microbial community. 2019. npj biofilms and microbiomes 5, 1. https://doi.org/10.1038/s41522-018-0076-z.
2.Yingying Cheng, Yong Chen, Yang Liu, et al. 2020. Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris. Emerging Microbes & Infections, 9(1):1843–1852. https://doi.org/10.1080/22221751.2020.1803769.
3.Yingying Cheng, Yang Liu, Yong Chen, et al. 2021. Sporadic Dissemination of tet(X3) and tet(X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter. Microbiology Spectrum, 9(3):e0114121. https://doi.org/10.1128/Spectrum.01141-21.
4.Yingying Cheng, Xiaoling Liu, Shuwen An, et al. 2013. A Nonribosomal Peptide Synthase Containing a Stand-Alone Condensation Domain Is Essential for Phytotoxin Zeamine Biosynthesis. Molecular Plant-Microbe Interactions, 26(11):1294-301. https://doi.org/10.1094/MPMI-04-13-0098-R.
5.Yingying Cheng, Yong Chen, Yang Liu, et al. 2021. Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri. Journal of Global Antimicrobial Resistance, 25:132-136. https://doi.org/10.1016/j.jgar.2021.03.004.
6.Yingying Cheng, Lisheng Liao, Changqing Chang, et al. 2016. A Sfp-type phosphopantetheinyl transferase ZmsO is essential for zeamines production and the virulence of Dickeya zeae. European Journal of Plant Pathology, 146:937-948. https://doi.org/10.1007/s10658-016-0971-1.
7.Zilin Zhuang, Yingying Cheng, Jie Deng, et al. 2024. Genomic insights into the phage-defense systems of Stenotrophomonas maltophilia clinical isolates. Microbiological Research, 278:127528. https://doi.org/10.1016/j.micres.2023.127528.
8.J. K. H. Yam, T. T. Aung, S. L. Chua, Yingying Cheng, et al. 2022. Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa. Infection and Immunity, 18;90(8):e0006122. https://doi.org/10.1128/iai.00061-22.
9.Xiaolin Liu, Zhiming Ma, Tuan Minh Tran, Carsten Rautengarten, Yingying Cheng, et al. 2023. Balanced callose and cellulose biosynthesis in Arabidopsis quorum-sensing signaling and pattern-triggered immunity. Plant Physiology, 194(1):137-152. https://doi.org/10.1093/plphys/kiad473.
10.Christian Wiraja, Malathi Mathiyazhakan, Fatemeh Movahedi, Paul Kumar Upputuri, Yingying Cheng, et al. 2016. Bioengineering & Translational Medicine, 1(3):357-364. https://doi.org/10.1002/btm2.10020.


