徐寅泰（xuyintai@bgi.com），技术研发经理。擅长蛋白质组学，尤其是糖基化等翻译后修饰的技术开发及应用，带领团队围绕糖基化建立了全球领先的完整糖肽、GlycoRNA与分子表征鉴定平台，以及依赖非依赖质谱的血浆蛋白质组超高深度检测方法。在Nature Methods、Analytical Chemistry与Molecular&Cellular Proteomics等杂志上发表12篇SCI文章。
研究方向：蛋白质组
现任岗位：华大股份 质谱业务部 技术研发经理
教育背景：西北大学 生物化学与分子生物学 硕士
参与项目：
1.依赖非依赖质谱的血浆蛋白质组超高深度检测方法建立
2.GlycoRNA鉴定方法建立
3.分子表征方法建立
4.完整糖肽鉴定方法建立
论文:
1.Li P, Chen Z, You S, Xu Y, Hao Z, Liu D, Shen J, Zhu B, Dan W, Sun S. Application of StrucGP in medical immunology: site-specific N-glycoproteomic analysis of macrophages. Front Med. 2023 Apr;17(2):304-316.
2.Xin M, You S, Wu J, Xu Y, Li C, Zhu B, Shen J, Chen Z, Dang L, Dan W, Zhang X, Sun S. Evaluation of absorbent cotton for glycopeptide enrichment. Anal Bioanal Chem. 2022 Dec;414(29-30):8245-8253.
3.Zhu B, Chen Z, Shen J, Xu Y, Lan R, Sun S. Structural- and Site-Specific N-Glycosylation Characterization of COVID-19 Virus Spike with StrucGP. Anal Chem. 2022 Sep 13;94(36):12274-12279.
4.Xin M#, Xu Y#, You S, Li C, Zhu B, Shen J, Chen Z, Shi W, Xue X, Shi J, Sun S. Precision Structural Interpretation of Site-Specific N-Glycans in Seminal Plasma. J Proteome Res. 2022 Jul 1;21(7):1664-1674.
5.Xin M#, You S#, Xu Y#, Shi W, Zhu B, Shen J, Wu J, Li C, Chen Z, Su Y, Shi J, Sun S. Precision Glycoproteomics Reveals Distinctive N-Glycosylation in Human Spermatozoa. Mol Cell Proteomics. 2022 Apr;21(4):100214.
6.Zhi Y, Jia L, Shen J, Li J, Chen Z, Zhu B, Hao Z, Xu Y, Sun S. Formylation: an undesirable modification on glycopeptides and glycans during storage in formic acid solution. Anal Bioanal Chem. 2022 May;414(11):3311-3317.
7.Shen J, Jia L, Dang L, Su Y, Zhang J, Xu Y, Zhu B, Chen Z, Wu J, Lan R, Hao Z, Ma C, Zhao T, Gao N, Bai J, Zhi Y, Li J, Zhang J, Sun S. StrucGP: de novo structural sequencing of site-specific N-glycan on glycoproteins using a modularization strategy. Nat Methods. 2021 Aug;18(8):921-929.
8.Li P, Hao Z, Wu J, Ma C, Xu Y, Li J, Lan R, Zhu B, Ren P, Fan D, Sun S. Comparative Proteomic Analysis of Polarized Human THP-1 and Mouse RAW264.7 Macrophages. Front Immunol. 2021 Jun 29;12:700009.
9.Li P, Hao Z, Liu H, Zhu B, Dang L, Ma C, Xu Y, Zhang Y, Fan D, Sun S. Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets. Biology (Basel). 2021 Mar 23;10(3):250.
10.Lan R, Xin M, Hao Z, You S, Xu Y, Wu J, Dang L, Zhang X, Sun S. Biological Functions and Large-Scale Profiling of Protein Glycosylation in Human Semen. J Proteome Res. 2020 Oct 2;19(10):3877-3889.
专利：
1.孙士生；申洁晨；苏远杰；徐寅泰，一种针对待测样本构建N-连接糖链分支结构数据库的方法，中国，CN202011216918.1，2021.02.05
