Miguel Angel Esteban（miguelesteban@genomics.cn），博士，研究员。我国”973“项目首位外裔首席科学家（2011），自2008年全职来华工作至今独立承担“973”项目、国家重点研发课题等各类基金项目25项，经费总额达7128万元。先后在国际一流期刊Nature、Cell、Nature Methods 、Cell Stem Cell、Nature Cell Biolog、Nature Genetics、Nature Materials等杂志累计发表及参与发表SCI论文102篇。Miguel A. Esteban研究员主要致力于早期胚胎发育、体细胞重编程及多能性的维持或转换、RNA生物学和神经退行性疾病，高通量单细胞组学、时空组学等方面的研究，在相关领域作出了系统性与创新性的工作，开创了干细胞领域研究的新局面。
研究方向：早期胚胎发育、体细胞重编程及多能性的维持或转换、RNA生物学和神经退行性疾病，高通量单细胞组学、时空组学
现任岗位：华大大细胞专项 研究科学家
教育背景：马德里自治大学 生物化学与分子生物学专业 博士
论文:
1.Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell, 2010. 6(1): 71-79. IF: 24.633
2.Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q,Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA*, and Pei D. A mesenchymal-to- epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell, 2010. 7(1): 51-63. Corresponding author. IF: 24.633
3.Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA*. Generation of human induced pluripotent stem cells from urine. Journal of the American Society of Nephrology, 2011. 22(7): 1221-8. Corresponding author. IF: 10.121
4.Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C,Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D,Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA*. Transcriptional Pause Release Is a RateLimiting Step for Somatic Cell Reprogramming. Cell Stem Cell, 2014. 15(5): 574-88. Corresponding author. IF: 24.633
5.Bao X, Wu H, Zhu X, Guo X, Hutchins A, Luo Z, Song H, Chen Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Dongye Wang, Qin B, Frampton J, Tse HF, Pei D, Wang H, and Zhang B, Esteban MA*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Research, 2015. 25(1): 80-92. Corresponding author. IF: 25.617
6.Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y,Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA*. Capturing the interactome of newly transcribed RNA. Nature Methods, 2018. 15(3): 213-220. Corresponding author. IF: 28.547
7.Zhuang Q, Li W, Benda C, Huang Z, Ahmed T, Liu P, Guo X, Ibañez DP, Luo Z, Zhang M, Abdul MM, Yang Z, Yang J, Huang Y, Zhang H, Huang D, Zhou J, Zhong X, Zhu X, Fu X, Fan W, Liu Y, Xu Y, Ward C, Khan MJ, Kanwal S, Mirza B, Tortorella MD, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP, Esteban MA*. NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology, 2018. 20(4): 400-412. Corresponding author. IF: 28.824
8.Abdul M, Ward C, Luo Z, Liu C, Li Y, Lai Y, Wu L, Li J, Jia W, Jiang Y,Liu H, Fu L, Yang Y, Ibañez D, Lai J, Wei X, An J, Guo P, Yuan Y, Deng Q, Wang Y, Liu Y, Gao F, Wang J, Zaman S, Qin B, Wu G, Maxwell P, Xu X, Liu L, Li L, Esteban MA*. Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage. Nature 2022. 605(7909):315-324. Corresponding author. IF: 49.962
9.Han L, Wei X, Liu C, Volpe G, Zhuang Z, Zou X, Wang Z, Pan T, Yuan Y, Zhang X, Fan P, Guo P, Lai Y, Lei Y, Liu X, Yu F, Shangguan S, Lai G, Deng Q, Liu Y, Wu L, Shi Q, Yu H, Huang Y, Cheng M, Xu J, Liu Y, Wang M, Wang C, Zhang Y, Xie D, Yang Y, Yu Y, Zheng H, Wei Y, Huang F, Lei J, Huang W, Zhu Z, Lu H, Wang B, Wei X, Chen F, Yang T, Du W, Chen J, Xu S, An J, Ward C, Wang Z, Pei Z, Wong C, Liu L, Zhang H, Liu M, Qin B, Schambach A, Isern J, Feng L, Liu Y, Guo X, Liu Z, Sun Q, Maxwell P, Barker N, Muñoz-Cánoves P, Gu1 Y, Mulder J, Uhlen M, Tan T, Liu S, Yang H, Wang J, Hou Y, Xu X,Esteban MA*, Liu L. Cell transcriptomic atlas of the non-human primate Macaca fascicularis. Nature 2022.604(7907):723-731. Corresponding author. IF: 49.962
10.Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J,Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Muñoz-Cánoves P, Maxwell P, Thiery J, Wu Q, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei J, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F , Yin Y, Yang H, Lisby M, Cornall R, Mulder J, Uhlen M, Esteban MA*, Li Y, Liu L, Xu X, Wang J. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays. Cell 2022. 185(10):1777-1792. Corresponding author. IF: 41.582
