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徐讯

徐讯(xuxun@genomics.cn)博士,华大生命科学研究院院长。曾获得科技部大挑战青年科学家、鹏城杰出人才奖、广东省科学技术奖一等奖、深圳市科学技术奖一等奖、谈家桢生命科学产业化奖等,入选百千万人才工程“有突出贡献中青年专家”,享受国务院特殊津贴。

研究方向:1. 基因测序仪及相关技术开发、单细胞测序技术、时空组测序技术 2. 测序技术在疾病和农业领域的转化应用研究等。

现任岗位:深圳华大生命科学研究院院长
参与项目:

1.新型基因编辑体系挖掘及高通量鉴定关键特性

2.深圳合成生物学创新研究院专项项目-高通量 DNA 合成仪研发( 2021 年)

3.深圳合成生物学创新研究院专项项目-高通量 DNA 合成仪研发( 2022 年)

4.高分辨率时空组学技术(项目:高精度全景转录组深度解析技术)

论文:

1.Han L, ..., Xu X, Esteban MA, Liu L. Cell transcriptomic atlas of the non-human primate Macaca fascicularis. Nature. 2022 Apr;604(7907):723-731. doi: 10.1038/s41586-022-04587-3. Epub 2022 Apr 13. PMID: 35418686.(中科院一区, IF: 69.504)

2.Chen A, ..., Xu X, Wang J. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 2022 May 12;185(10):1777-1792.e21. doi: 10.1016/j.cell.2022.04.003. Epub 2022 May 4. PMID: 35512705. (中科院一区, IF: 66.85)

3. Wei X, ..., Xu X, Fei JF, Gu Y. Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration. Science. 2022 Sep 2;377(6610):eabp9444. doi: 10.1126/science.abp9444. Epub 2022 Sep 2. PMID: 36048929. (中科院一区, IF: 63.714)

4. Zhang L, ..., Xu X, Wang X. Clinical and translational values of spatial transcriptomics. Signal Transduct Target Ther. 2022 Apr 1;7(1):111. doi: 10.1038/s41392-022-00960-w. PMID: 35365599; PMCID: PMC8972902. (中科院一区, IF: 38.104)

5. Lei Y, ..., Xu X. Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex. Nat Commun. 2022 Nov 8;13(1):6747. doi: 10.1038/s41467-022-34413-3. PMID: 36347848; PMCID: PMC9643508. (中科院一区, IF: 17.694)

6.Shen R, ..., Xu X, Yao J. Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding. Nat Commun. 2022 Dec 10;13(1):7640. doi: 10.1038/s41467-022-35288-0. PMID: 36496406; PMCID: PMC9741613. (中科院一区, IF: 17.694)

7. Ou Z, ..., Xu X, Wang Y, Li J, Wu P. Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma. Adv Sci (Weinh). 2022 Oct;9(29):e2203040. doi: 10.1002/advs.202203040. Epub 2022 Aug 19. PMID: 35986392; PMCID: PMC9561780. (中科院一区, IF: 17.521)

8.Xia K, ..., Xu X. The single-cell stereo-seq reveals region-specific cell subtypes and transcriptome profiling in Arabidopsis leaves. Dev Cell. 2022 May 23;57(10):1299-1310.e4. doi: 10.1016/j.devcel.2022.04.011. Epub 2022 May 4. PMID: 35512702. (中科院一区, IF: 13.417)

9. Chen A, ..., Xu X, Li C. Single-cell spatial transcriptome reveals celltype organization in the macaque cortex. Cell. 2023 Aug 17;186(17):3726- 3743.e24. doi: 10.1016/j.cell.2023.06.009. Epub 2023 Jul 12. PMID: 37442136. (中科院一区, IF: 64.5)

10. Hao F, ..., Xu X, Yang H, Macknight RC, Wang W, Cai J. Chromosomelevel genomes of three key Allium crops and their trait evolution. Nat Genet. 2023 Nov;55(11):1976-1986. doi: 10.1038/s41588-023-01546-0. Epub 2023 Nov 6. Erratum in: Nat Genet. 2024 Jan;56(1):187. doi: 10.1038/s41588-023-01610-9. PMID: 37932434. (中科院一区, IF: 30.8)

11.Xu Z, ..., Xu X, Wei X. STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization. Nucleic Acids Res. 2024 Jan 5;52(D1):D1053-D1061. doi: 10.1093/nar/gkad933. PMID: 37953328; PMCID: PMC10767841. (中科院二区, IF: 14.9)

12. Lei Y, ..., Xu X, Liu S, Zhang Z, Liu T. Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus. Cell Metab. 2024 Feb 6;36(2):438-453.e6. doi: 10.1016/j.cmet.2024.01.003. PMID: 38325338. (中科院一区, IF: 29)

13.Xu J, ..., Xu X, Liu L, Chen A, Lai Y, Esteban MA. A spatiotemporal atlas of mouse liver homeostasis and regeneration. Nat Genet. 2024 May;56(5):953-969. doi: 10.1038/s41588-024-01709-7. Epub 2024 Apr 16. PMID: 38627598. (中科院一区, IF: 30.8)

14. Long Y, ..., Xu X, Chen J. Deciphering spatial domains from spatial multi-omics with SpatialGlue. Nat Methods. 2024 Jun 21. doi: 10.1038/s41592- 024-02316-4. Epub ahead of print. PMID: 38907114. (中科院一区, IF: 36.1)

15.Liu L, ..., Xu X. Spatiotemporal omics for biology and medicine. Cell. 2024 Aug 22;187(17):4488-4519. doi: 10.1016/j.cell.2024.07.040. PMID: 39178830. (中科院一区, IF: 45.5)

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