倪梦（nimeng@genomics.cn），博士。华大基因智惠医学研究院千万微生态专项科学家。博士毕业于香港中文大学，卢煜明院士团队完成博后工作。在生物信息学、生物医学大数据分析方向有丰富的研究经验，曾以正常组织类器官、肿瘤类器官、小鼠模型和临床样本外周血标本为基础，系统研究细胞游离DNA在小鼠、正常器官以及肿瘤细胞的产生机制，解析肿瘤细胞游离DNA的碎片化模式，并以第一作者身份（含共一）在AJHG, Genome Research, PNAS, PLoS Genetics, Cancer Discovery等期刊发表多篇研究论文，并获批3项发明专利。
研究方向：微生态与慢病肿瘤精神健康类项目
现任岗位：华大股份 智惠医学研究院 专项科学家
教育背景：香港中文大学分子生物技术博士
论文:
1.Nuclease deficiencies alter plasma cell-free DNA methylation profiles
2.Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
3.The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB
4.Coordinated regulation of core and accessory genes in the multipartite genome of Sinorhizobium fredii
5.Plasma DNA end motif profiling as a fragmentomic marker in cancer, pregnancy and transplantation
6.Plasma DNA end motif profiling as a fragmentomic marker in cancer, pregnancy and transplantation
7.Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling
8.ABAS1 from soybean is a 1R-subtype MYB transcriptional repressor that enhances ABA sensitivity
9.Differentially expressed microRNAs that target functional genes in mature soybean nodules
专利：
1. Lo YMD, Chiu RWK, Chan KCA, Chan CRW, Jiang P, Ni M., Han SCD, and Sin TK, CELL-FREE DNA METHYLATION AND NUCLEASE-MEDIATED FRAGMENTATION. U.S. Patent, filed March 1, 2022, published October 13, 2022. WO22214051A1
2. Lo YMD, Chiu RWK, Han SCD, and Ni M. BITERMINAL DNA FRAGMENT TYPES IN CELL-FREE SAMPLES AND USES THEREOF. U.S. Patent, filed Jan 08, 2021, published July 15, 2021. WO2021139716A1.
3. Lo YMD, Chiu RWK, Han SCD, and Ni M. CELL-FREE DNA FRAGMENTATION AND NUCLEASES. U.S. Patent, filed Dec 18, 2020, published June 14, 2021. US 20210189494A1
