肖亮(xiaoliang@genomics.cn)。深圳华大生命科学院宏基因组研究中心负责人,深圳市人体 共生微生物检测与干预工程实验室主任,华南农业大学兼职教授,西北大学(西安) 兼职教授,郑州大学硕士生导师,国家自然科学基金委函评专家。作为项目负责人主持国自然面上项目一项及深圳市百万 级技术开发项目一项,参与国家、省市级科研项目多项。现主要从事人体健康相关 宏基因组学方面的科学研究与干预产品研发工作。
研究方向:微生物学、生物信息学
现任岗位:华大研究院 精准健康研究所 执行所长
教育背景:理学博士 微生物学 南开大学
参与项目:
1. 利用多组学手段研究肠道微生态与食物过敏之间的关联,国家自然科学基金面上项目,主持
2. 肠道与下丘脑在糖尿病发生发展中的作用及干预新方案研究,国家重点研发计划,课题骨干
3. 特殊保障食品制造关键技术研究及新产品创制/水下长航特殊食品制造关键技术研究与新产品创制,国家重点研发计划,课题骨干
4. 基于多组学特征谱急性胃肠损伤标志物的开发与应用,广州市科技计划,子课题负责人
5. 海洋多糖配合益生菌制剂调节肠道菌群防治帕金森病的临床研究,深圳市科创委学科布局,子课题负责人
6. 深圳市人体肠道微生态检测与干预工程实验室,实验室负责人
论文:
1. Wang, M., Hu, T., Lin, X., Liang, H., Li, W., Zhao, S., Zhong, Y., Zhang, H., Ge, L., Jin, X., Xiao, L. & Zou, Y. Probiotic characteristics of Lactobacillus gasseri TF08-1: A cholesterol-lowering bacterium, isolated from human gut. Enzyme Microb. Technol. 169, 110276 (2023).(IF 3.4,通讯作者)
2. Qi, F., Fan, S., Fang, C., Ge, L., Lyu, J., Huang, Z., Zhao, S., Zou, Y., Huang, L., Liu, X., Liang, Y., Zhang, Y., Zhong, Y., Zhang, H., Xiao, L. & Zhang, X. Orally administrated Lactobacillus gasseri TM13 and Lactobacillus crispatus LG55 can restore the vaginal health of patients recovering from bacterial vaginosis. Front. Immunol. 14, 1125239 (2023). (IF 7.3,通讯作者)
3. Lin, X., Hu, T., Chen, J., Liang, H., Zhou, J., Wu, Z., Ye, C., Jin, X., Xu, X., Zhang, W., Jing, X., Yang, T., Wang, J., Yang, H., Kristiansen, K., Xiao, L. & Zou, Y. The genomic landscape of reference genomes of cultivated human gut bacteria. Nat. Commun. 14, 1663 (2023). (IF 17.7,通讯作者)
4. Li, W., Liang, H., Lin, X., Hu, T., Wu, Z., He, W., Wang, M., Zhang, J., Jie, Z., Jin, X., Xu, X., Wang, J., Yang, H., Zhang, W., Kristiansen, K., Xiao, L. & Zou, Y. A catalog of bacterial reference genomes from cultivated human oral bacteria. Npj Biofilms Microbiomes 9, 1–13 (2023).(IF 7.2,通讯作者)
5. Du, B., Xiao, X., Wang, H., Li, W., Xia, Z., Yang, P., Huang, S.-K., Yuan, R., Liu, J., Han, M., Zou, Y., Zhu, J., He, D., Lyu, J., Jin, X., Xu, X., Wang, J., Yang, H., Xiao, L., Liu, X. & Kristiansen, K. Evaluation of the Impact of BaP Exposure on the Gut Microbiota and Allergic Responses in an OVA-Sensitized Mouse Model. Environ. Health Perspect. 131, 067004 (2023).(IF 10.4,通讯作者)
6. Zou, Y., Xue, W., Lin, X., Lv, M., Luo, G., Dai, Y., Sun, H., Liu, S., Sun, C., Hu, T. & Xiao, L. Butyribacter intestini gen. nov., sp. nov., a butyric acid-producing bacterium of the family Lachnospiraceae isolated from human faeces, and reclassification of Acetivibrio ethanolgignens as Acetanaerobacter ethanolgignens gen. nov., comb. nov. Syst. Appl. Microbiol. 44, 126201 (2021). (IF 3.4,通讯作者)
7. Zhu, J., Ren, H., Zhong, H., Li, X., Zou, Y., Han, M., Li, M., Madsen, L., Kristiansen, K. & Xiao, L. An Expanded Gene Catalog of Mouse Gut Metagenomes. mSphere 6, e01119-20 (2021).IF(IF 5.0,通讯作者)
8. Chen, J., Wang, Q., Hao, Z., Li, Z., Sahu, S. K., Liu, H. & Xiao, L. Relationship between the Gut Microbiome and Energy/Nutrient Intake in a Confined Bioregenerative Life Support System. Appl. Environ. Microbiol. 86, e02465-19 (2020). (IF 4.4,通讯作者)
9. Zou, Y., Xue, W., Luo, G., Deng, Z., Qin, P., Guo, R., Sun, H., Xia, Y., Liang, S., Dai, Y., Wan, D., Jiang, R., Su, L., Feng, Q., Jie, Z., Guo, T., Xia, Z., Liu, C., Yu, J., Lin, Y., Tang, S., Huo, G., Xu, X., Hou, Y., Liu, X., Wang, J., Yang, H., Kristiansen, K., Li, J., Jia, H. & Xiao, L. 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses. Nat. Biotechnol. 37, 179–185 (2019). (IF 46.9,通讯作者)
10. Qin, P., Zou, Y., Dai, Y., Luo, G., Zhang, X. & Xiao, L. Characterization a Novel Butyric Acid-Producing Bacterium Collinsella aerofaciens Subsp. Shenzhenensis Subsp. Nov. Microorganisms 7, 78 (2019). (IF 4.5,通讯作者)
11. Xiao, L., Sonne, S. B., Feng, Q., Chen, N., Xia, Z., Li, X., Fang, Z., Zhang, D., Fjære, E., Midtbø, L. K., Derrien, M., Hugenholtz, F., Tang, L., Li, J., Zhang, J., Liu, C., Hao, Q., Vogel, U. B., Mortensen, A., Kleerebezem, M., Licht, T. R., Yang, H., Wang, J., Li, Y., Arumugam, M., Wang, J., Madsen, L. & Kristiansen, K. High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice. Microbiome 5, 43 (2017). (IF 15.5,第一作者)
12. Xiao, L., Estellé, J., Kiilerich, P., Ramayo-Caldas, Y., Xia, Z., Feng, Q., Liang, S., Pedersen, A. Ø., Kjeldsen, N. J., Liu, C., Maguin, E., Doré, J., Pons, N., Le Chatelier, E., Prifti, E., Li, J., Jia, H., Liu, X., Xu, X., Ehrlich, S. D., Madsen, L., Kristiansen, K., Rogel-Gaillard, C. & Wang, J. A reference gene catalogue of the pig gut microbiome. Nat. Microbiol. 1, 1–6 (2016). (IF 28.3,第一作者)
13. He, Q., Li, X., Liu, C., Su, L., Xia, Z., Li, X., Li, Y., Li, L., Yan, T., Feng, Q. & Xiao, L. Dysbiosis of the fecal microbiota in the TNBS-induced Crohn’s disease mouse model. Appl. Microbiol. Biotechnol. 100, 4485–4494 (2016). (IF 5.0,通讯作者)
14. Xiao, L., Feng, Q., Liang, S., Sonne, S. B., Xia, Z., Qiu, X., Li, X., Long, H., Zhang, J., Zhang, D., Liu, C., Fang, Z., Chou, J., Glanville, J., Hao, Q., Kotowska, D., Colding, C., Licht, T. R., Wu, D., Yu, J., Sung, J. J. Y., Liang, Q., Li, J., Jia, H., Lan, Z., Tremaroli, V., Dworzynski, P., Nielsen, H. B., Bäckhed, F., Doré, J., Le Chatelier, E., Ehrlich, S. D., Lin, J. C., Arumugam, M., Wang, J., Madsen, L. & Kristiansen, K. A catalog of the mouse gut metagenome. Nat. Biotechnol. 33, 1103–1108 (2015). (IF 46.9,第一作者)
专利:
1. 卷曲乳杆菌在治疗或预防类风湿性关节炎中的应用
2. 克里斯坦森氏菌(Christensenella intestinihominis)及其应用
3. 华德萨特氏菌仔治疗或预防类风湿性关节炎或其相关疾病中的应用
4. 极巨巨单胞菌在治疗或预防类风湿性关节炎中的应用
5. 一种假小链状双歧杆菌及其培养方法和应用
6. 粪副拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
7. 单形巨单胞菌(Megamonas funiformis)及其应用
8. 解纤维素拟杆菌(Bacteroides cellulosilyticus)在预防和/或治疗脂质代谢性相关疾病方面的应用
9. 丁酸杆菌(Butyribacter intestini)在预防和/或治疗炎症相关疾病的应用
10. 加氏乳杆菌在预防和或治疗代谢性疾病中的用途和组合物
11. 用于预防和/或治疗生殖道菌群紊乱和/或骨质流失引起的疾病的鼠李糖乳杆菌
12. 用于保存生物样本的稳定剂
Research Gate 链接:
https://www.researchgate.net/profile/Xiao-Liang-41
Google Scholar链接:
https://scholar.google.com/citations?hl=zh-CN&authuser=1&user=NbOwlrMAAAAJ


