孙井花（sunjinghua@genomics.cn）。主要从事妊娠疾病的多组学研究，特别关注血浆游离RNA在妊娠疾病的应用的研究。
研究方向：母婴健康多组学研究
现任岗位：华大生物信息副研究员
教育背景：博士 基因组学 中国科学院大学
参与项目:
1.基于血浆游离RNA预测多种妊娠并发症
2.血浆游离RNA新建库方法PALM-seq的开发
3.与自发性流产相关的基因组变异
论文:
1.Jinghua Sun, Wen-Jing Wang, Xuanyou Zhou, Tingyu Yang, Mujin Ye, Weihui Shi, Zhongzhen Liu, Lanlan Zhang, Qing Zhou, Yulong Qin, Yiyao Chen, Fang Chen, Hefeng Huang, Songchang Chen, Chenming Xu. Early characterisation and prediction of liver diseases in pregnancy by plasma cell-free RNAs. Clin Transl Med. 2023 Oct;13(10):e1439. doi: 10.1002/ctm2.1439.
2. Jinghua Sun, Xi Yang, Taifu Wang, Yanru Xing, Haixiao Chen, Sujun Zhu, Juan Zeng, Qing Zhou, Fang Chen, Xiuqing Zhang, Wen-Jing Wang. Evaluating the Effects of Storage Conditions on Multiple Cell-Free RNAs in Plasma by High-Throughput Sequencing. Biopreserv Biobank. 2022 Aug 24. doi: 10.1089/bio.2022.0004.
3. Taifu Wang, Jinghua Sun, Xiuqing Zhang, Wen-Jing Wang, Qing Zhou. CNV-P: a machine-learning framework for predicting high confident copy number variations. PeerJ. 2021 Dec 2;9:e12564. doi: 10.7717/peerj.12564.
4. Zunmin Wan, Xiaohong Li, Jinghua Sun, Xiaohua Li, Zhongzhen Liu, Haojian Dong, Qing Zhou, Hailong Qiu, Jinjin Xu, Tingyu Yang, Wen-Jing Wang, Yanqiu Ou. Peripheral Blood Transcripts Predict Preoperative Obstructive Total Anomalous Pulmonary Venous Connection. Front Cardiovasc Med. 2022 May 31;9:892000. doi: 10.3389/fcvm.2022.892000.
5. Zhongzhen Liu, Taifu Wang, Xi Yang, Qing Zhou, Sujun Zhu, Juan Zeng, Haixiao Chen, Jinghua Sun, Liqiang Li, Jinjin Xu, Chunyu Geng, Xun Xu, Jian Wang, Huanming Yang, Shida Zhu, Fang Chen, Wen-Jing Wang. Polyadenylation ligation-mediated sequencing (PALM-Seq) characterizes cell-free coding and non-coding RNAs in human biofluids. Clin Transl Med. 2022 Jul;12(7):e987. doi: 10.1002/ctm2.987.
6. Zhong-Zhen Liu, Jing-Hua Sun, Wen-Jing Wang. Gut microbiota in gastrointestinal diseases during pregnancy. World J Clin Cases. 2022 Apr 6;10(10):2976-2989. doi: 10.12998/wjcc.v10.i10.2976.
7. Jia Kang, Qing Zhou, Na Chen, Zhongzhen Liu, Ye Zhang, Jinghua Sun, Congcong Ma, Fang Chen, Yidi Ma, Lin Wang, Lan Zhu, Wen-Jing Wang. Clinical and Genetic Characteristics of a Cohort with Distal Vaginal Atresia. Int J Mol Sci. 2022 Oct 25;23(21):12853. doi: 10.3390/ijms232112853.
专利:
1. 王泰福，周青，孙井花，王文婧。确定核酸样本中CNV的方法、装置及应用。申请号：202010261297.2。
2. 徐晨明，孙井花，陈松长，王文婧，黄荷凤，徐讯，刘忠振。标志物在制备预测妊娠期肝内胆汁淤积症的相关产品中的应用。申请号：202111518803.2。
3. 王文婧，徐晨明，陈松长，孙井花，黄荷凤，徐讯，刘忠振。基因标志物在预测孕妇早产风险中的应用。申请号：PCT/CN2021/136566。
4. 徐晨明，王琳，陈松长，王文婧，黄荷凤，徐讯，孙井花。基因标志物在预测孕妇子痫前期风险中的应用。申请号：PCT/CN2021/136842。
Research Gate链接：
https://www.researchgate.net/scientific-contributions/Jinghua-Sun-2159558200
