彭丽花(penglihua@genomics.cn)。主要从事癌症基因组学、转录组学、免疫基因组、单细胞转录组和空间转录组等多组学数据挖掘以及癌症发生发展机制研究,主攻肿瘤克隆演化与免疫微环境相互作用方向,先后负责肝胆肿瘤、肾癌等多种癌种的免疫基因组或空间转录组研究项目,目前已在《Cancer Discovery》、《Journal of Hepatology》等发表多篇SCI文章,其中一作4篇。
研究方向:肿瘤免疫基因组学
现任岗位:生物信息副研究员,华大研究院-精准健康研究所
教育背景:硕士 基因组学 中国科学院大学
参与项目:
1.肾细胞癌合并静脉癌栓的时空组学研究
2.肝内胆管癌免疫微环境异质性研究
3.结直肠癌肝转移免疫微环境异质性研究
4.基于多组学联合分析的肝癌转移机制研究
论文:
1.Lin Y, Peng L, Dong L, et al. Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma[J]. Cancer Discovery, 2022, 12(10): 2350-2371
2. Dong L, Peng L, Ma L, et al. Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma[J]. Journal of hepatology, 2020, 72(5): 896-908.
3. Rao J, Peng L, Liang X, et al. Performance of copy number variants detection based on whole-genome sequencing by DNBSEQ platforms[J]. BMC bioinformatics, 2020, 21: 1-14.
4. Peng L, Xing R, Liu D, et al. Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing[J]. Science bulletin, 2019, 64(4): 236-244.
5. Ren S, Wei G, Liu D, Wang L, Hou Y, Zhu S, Peng L et al. Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression[J]. European urology, 2018, 73(3): 322-339.


