聂超（niechao@genomics.cn）。博士，研究员。现任深圳华大生命科学主任科学家，深圳市认知与基因研究重点实验室副主任，中国遗传学会衰老遗传学分会委员。华大学院博士生导师，兼任中国农业大学、西安交通大学、郑州大学、河北医科大学、喀什大学、清华大学深圳研究生院等大学校外导师。华大集团2021年度“明星讲师”。
研究方向：大人群多组学、健康与衰老研究
现任岗位：主任科学家，华大研究院-精准健康研究所
教育背景：博士，基因组学，中国科学院大学
参与项目:
一直从事大人群大数据多组学、主动健康与衰老研究，主持或参与中国慢性病前瞻性研究（CKB）、中国老年人健康长寿影响因素调查研究（CLHLS）、中国健康与养老追踪调查(charls)、华大健康多组学队列等，近年来在国际知名期刊上发表30多篇文章，包括Cell、Cell Reports Medicine、Nature Communication、Aging Cell、 Microbiome、Cell Reports、Molecular Psychiatry、Advanced Science等国际一流期刊；被引用2000多次，H指数18。申请国家发明专利14项，PCT专利2项；国家973课题、国家重点研发计划、国家科技创新“2030”等重点研发项目核心骨干成员，另参与或主持科技部项目、美国NIH项目、国自然地区项目、深圳市科创委项目多项。主要研究成果：1、健康老龄人群及长寿老人相关队列的基因组、多组学研究，鉴定了新的长寿基因与变异，长寿的性别差异，长寿与复杂疾病的关系等；2、人群队列的多组学研究，在世界上首次使用多组学数据构建器官生物学年龄和Life Index，表明其可以用来监测疾病和亚健康状态，并指导精准干预；3、在认知与基因研究方面，首次实现脑影像-血液代谢组-肠道微生物的相关性研究 ；鉴定了新的神退疾病生物标志物。
论文:
1.Ma S, Ji Z, Zhang B, et al. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging[J]. Cell, 2024.
2.Nie C, Li Y, Li R, et al. Distinct biological ages of organs and systems identified from a multi-omics study[J]. Cell reports, 2022, 38(10).
3.Zhang W, Wan Z, Li X, et al. A population-based study of precision health assessments using multi-omics network-derived biological functional modules[J]. Cell Reports Medicine, 2022, 3(12).
4.Zeng Y, Nie C, Min J, et al. Novel loci and pathways significantly associated with longevity. Sci Rep. 2016; 6: 21243[EB/OL].
5. Li Z, Ju Y, Xia J, et al. Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function[J]. Advanced Science, 2023, 10(28): 2300050.
6. Sun L, Li Z, Hu C, et al. Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging[J]. Aging Cell, 2023, 22(12): e14028.
7. Li Z, Lai J, Zhang P, et al. Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression[J]. Molecular psychiatry, 2022, 27(10): 4123-4135.
8. Liu X, Zou L, Nie C, et al. Mendelian randomization analyses reveal causal relationships between the human microbiome and longevity[J]. Scientific reports, 2023, 13(1): 5127.
9. Wang L, Zhen H, Sun Y, et al. Plasma Exo-miRNAs correlated with AD-related factors of Chinese individuals involved in Aβ accumulation and cognition decline[J]. Molecular Neurobiology, 2022, 59(11): 6790-6804.
10. Hu D, Li Y, Zhang D, et al. Genetic trade‐offs between complex diseases and longevity[J]. Aging Cell, 2022, 21(7): e13654.
11. Liu Z, Sun Y, Zhen H, et al. Network pharmacology integrated with transcriptomics deciphered the potential mechanism of codonopsis pilosula against hepatocellular carcinoma[J]. Evidence‐Based Complementary and Alternative Medicine, 2022, 2022(1): 1340194.
12. Liu C, Li Z, Ding J, et al. Species-level analysis of the human gut microbiome shows antibiotic resistance genes associated with colorectal cancer[J]. Frontiers in Microbiology, 2021, 12: 765291.
13. Li Z, Xia J, Jiang L, et al. Characterization of the human skin resistome and identification of two microbiota cutotypes[J]. Microbiome, 2021, 9: 1-18.
14. Hu D, Lu Y, Wang D, et al. Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection[J]. Scientific Reports, 2021, 11(1): 18235.
15. Kong F, Lv Z, Wang L, et al. RNA-sequencing of peripheral blood circular RNAs in Parkinson disease[J]. Medicine, 2021, 100(23): e25888.
16. Liu X, Song Z, Li Y, et al. Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals[J]. Aging Cell, 2021, 20(3): e13323.
17. Wang C, Chen B, Feng Q, et al. Clinical perspectives and concerns of metformin as an anti‐aging drug[J]. Aging Medicine, 2020, 3(4): 266-275.
18. Nie C, Sun Y, Zhen H, et al. Differential expression of plasma exo-miRNA in neurodegenerative diseases by next-generation sequencing[J]. Frontiers in Neuroscience, 2020, 14: 438.
19. Deelen J, Evans D S, Arking D E, et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes[J]. Nature communications, 2019, 10(1): 3669.
20. Zeng Y, Nie C, Min J, et al. Sex differences in genetic associations with longevity[J]. JAMA network open, 2018, 1(4): e181670-e181670.
21. Zhao X, Liu X, Zhang A, et al. The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese[J]. Aging (Albany NY), 2018, 10(6): 1206.
22. Grarup N, Sulem P, Sandholt C H, et al. Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets[J]. PLoS genetics, 2013, 9(6): e1003530.
23. Zeng Y, Chen H, Liu X, et al. Genetic associations with longevity are on average stronger in females than in males[J]. Heliyon, 2024, 10(1).
专利：
1.一种cot-1DNA、其制备方法及用途
2.METHOD AND SYSTEM FOR SCREENING NANOBODY
3.筛选纳米抗体的方法及系统
4.一种高纯度单克隆抗体的制备方法、单克隆抗体及应用
5.确定人群样本生物指标集、预测生物学年龄的方法及其应用
6.一种线粒体拷贝数和序列变异的检测方法
7.一种具有延缓机体衰老作用的组合物及其应用
Google scholar 链接：
https://scholar.google.com/citations?user=UcE_pHgAAAAJ&hl=zh-CN
