麻锦敏（majinmin@genomics.cn）。华大火眼工程首席技术官。华大股份染专项首席科学官。华大研究院病原实验室主任。
研究方向：微生物，病原微生物，宏基因组，免疫学,mRNA疫苗
现任岗位：事业部副总经理，华大孵化产业平台-火眼工程
教育背景：博士，分子生物医学，哥本哈根大学
参与项目:
1. 科技部战略性国际科技创新合作重点专项，《人、畜传染性疾病预防监控技术》，
2016YFE0205800，2017/09-2020/7，2000 万，已结题，子课题负责人。
2. 深圳科创委项目，《儿童手足口病重症全转录组研究》，JCYJ20150402111430623，2015/9-2017/8，30 万，已结题，骨干参加。
3. 深圳科创委项目，《新发重大传染病快速鉴定与个性化治疗研究》，2016/9-2019/7，JCYJ20160427151920801，200 万，已结题，骨干参加。
4. 国家科技重大专项，艾滋病和病毒性肝炎等重大传染病防治，《传染病实验室监测核心技术和技术体系研究》，2017/6-2019/12，2000万，已结题，子课题骨干。
5. 国家科技部中英合作项目, 2011DFA33220,《利用新一代测序技术对与人相关环境微生物的合作研究》,2012/4-2015/3,176 万，已结题，中方主要负责人。
6. 国家 863 项目，“利用遗传地理时空模型预测 H5N1 禽流感病毒的传播及控制策略研究”，2012/6-2015/5,150万，已结题，子课题《运用高通量测序研究流感病毒的遗传变异规律》主要骨干参加成员。
7. 深圳科创委项目，《病原性微生物感染与定植甄别研究》，JCYJ20170817145915789，2018/4-2020/4，50万，已结题，主持
8.国自然国际合作（中国-瑞典）项目，NO.82161138018，《呼吸系统感染与宿主反应特征标识筛查及快速检测方法研究》，2022/1-2024/12，270万，在研，子课题负责人
论文:
1. Zhao J, He X, Min J, et al (2023) A multicenter prospective study of comprehensive metagenomic and transcriptomic signatures for predicting outcomes of patients with severe community-acquired pneumonia. eBioMedicine 96:. https://doi.org/10.1016/j.ebiom.2023.104790
2. Zhang Y, Wang Q, Zhu Z, et al (2023) Tracing the Origin of Genotype II African Swine Fever Virus in China by Genomic Epidemiology Analysis. Transboundary and Emerging Diseases 2023:1–14. https://doi.org/10.1155/2023/4820809
3. Xu Y, Ma J, Ouyang W, et al (2023) Suppression of innate and acquired immunity in severe hand foot and mouth disease caused by EV71 infections in children. Clinical Immunology 248:. https://doi.org/10.1016/J.CLIM.2023.109260
4. Zhou Y, Lu S, Wei X, et al (2023) Metatranscriptomic Analysis Reveals Disordered Alterations in Oropharyngeal Microbiome during the Infection and Clearance Processes of SARS-CoV-2: A Warning for Secondary Infections. Biomolecules 13:. https://doi.org/10.3390/BIOM13010006
5. Ma J, Sabino-Santos G (2023) Editorial: Interactions between pathogens and host immune system in patients with immunodeficiency: estimation from high-throughput sequencing. Frontiers in Cellular and Infection Microbiology 13:. https://doi.org/10.3389/fcimb.2023.1200638
6. Lu S, Zhou Y, Hu Y, et al (2023) Metatranscriptomic analysis revealed Prevotella as a potential biomarker of oropharyngeal microbiomes in SARS-CoV-2 infection. Frontiers in Cellular and Infection Microbiology 13:. https://doi.org/10.3389/fcimb.2023.1161763
7. Fan S, He X, Zhu Z, et al (2023) Integrating host transcriptomic signatures for distinguishing autoimmune encephalitis in cerebrospinal fluid by metagenomic sequencing. Cell and Bioscience 13:. https://doi.org/10.1186/s13578-023-01047-x
8. Zhang C, Cheng H, Zhao Y, et al (2022) Evaluation of Cell-Free DNA-Based Next-Generation Sequencing for Identifying Pathogens in Bacteremia Patients. Polish Journal of Microbiology 71:499–507. https://doi.org/10.33073/PJM-2022-043
9. Gan H, Min J, Long H, et al (2022) Microbial and human transcriptional profiling of coronavirus disease 2019 patients: Potential predictors of disease severity. Frontiers in Microbiology 13:. https://doi.org/10.3389/FMICB.2022.959433
10. Xue S, Zheng T, Yan J, et al (2022) Identification of a 3-Gene Model as Prognostic Biomarker in Patients With Gastric Cancer. Frontiers in Oncology 12:. https://doi.org/10.3389/FONC.2022.930586
11. Wang D, Zhang T, Lu Y, et al (2022) Helicobacter pylori infection affects the human gastric microbiome, as revealed by metagenomic sequencing. FEBS Open Bio 12:1188–1196. https://doi.org/10.1002/2211-5463.13390
12. Shen C, Xu Y, Ji J, et al (2021) Intestinal microbiota has important effect on severity of hand foot and mouth disease in children. BMC Infectious Diseases 21:1062. https://doi.org/10.1186/s12879-021-06748-7
13. Liu X, Chen Y, Ouyang H, et al (2021) Tuberculosis Diagnosis by Metagenomic Next-generation Sequencing on Bronchoalveolar Lavage Fluid: a cross-sectional analysis. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2020.12.063
14. Liu L, Wu T, Liu B, et al (2021) The Origin and Molecular Epidemiology of Dengue Fever in Hainan Province, China, 2019. Frontiers in Microbiology 12:
15. Huang M, Ma J, Jiao J, et al (2021) The epidemic of q fever in 2018 to 2019 in zhuhai city of china determined by metagenomic next-generation sequencing. PLoS Neglected Tropical Diseases 15:. https://doi.org/10.1371/journal.pntd.0009520
16. Yang Q, Zhou Y, Ai J, et al (2020) Collaborated effort against SARS-CoV-2 outbreak in China. Clinical and Translational Medicine 10:13–16. https://doi.org/10.1002/ctm2.7
17. Wang L, Wang Z, Ma J, et al (2020) Comparison of Intraocular Antibody Measurement, Quantitative Pathogen PCR, and Metagenomic Deep Sequencing of Aqueous Humor in Secondary Glaucoma Associated with Anterior Segment Uveitis. Ocular Immunology and Inflammation. https://doi.org/10.1080/09273948.2020.1776883
18. Lu R, Zhao X, Li J, et al (2020) Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. https://doi.org/10.1016/S0140-6736(20)30251-8
19. Liu Y, Wang X, Zhu H, et al (2020) Recovered and Dead Outcome Patients Caused by Influenza a (H7N9) Virus Infection Show Different Pro-Inflammatory Cytokine Dynamics During Disease Progress and its Application in Real-Time Prognosis. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3216843
20. Li Y, Shen C, Yang L, et al (2020) Intra-host diversity of hepatitis B virus during mother-to-child transmission: the X gene may play a key role in virus survival in children after transmission. Archives of Virology 165:. https://doi.org/10.1007/s00705-020-04597-4
21. Li Y, Shen C, Yang L, et al (2020) Correction to: Intra-host diversity of hepatitis B virus during mother-to-child transmission: the X gene may play a key role in virus survival in children after transmission (Archives of Virology, (2020), 165, 6, (1279-1288), 10.1007/s00705-020-04597-4). Archives of Virology 165:. https://doi.org/10.1007/s00705-020-04636-0
22. Ji J, Li B, Li J, et al (2020) Comprehensive characterization of plasma cell-free echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0008148
23. Guo M, Liu G, Chen J, et al (2020) Dynamics of bacteriophages in gut of giant pandas reveal a potential regulation of dietary intake on bacteriophage composition. Science of the Total Environment 734:. https://doi.org/10.1016/j.scitotenv.2020.139424
24. Bi Y, Li J, Li S, et al (2020) Dominant subtype switch in avian influenza viruses during 2016–2019 in China. Nature Communications 11:. https://doi.org/10.1038/s41467-020-19671-3
25. Li Y, Fu X, Ma J, et al (2019) Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. Nature Communications 10:. https://doi.org/10.1038/s41467-019-10294-x
26. Zhang B, Kasoju N, Li Q, et al (2019) Culture surfaces induce hypoxia-regulated genes in human mesenchymal stromal cells. Biomedical Materials (Bristol) 14:. https://doi.org/10.1088/1748-605X/ab0e61
27. Li M, Wang B, Li L, et al (2019) Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection. Virologica Sinica 34:. https://doi.org/10.1007/s12250-019-00096-2
28. Ma J, Zhao F, Su W, et al (2018) Zinc finger and interferon-stimulated genes play a vital role in TB-IRIS following HAART in AIDS. Personalized Medicine 15:251–269. https://doi.org/10.2217/pme-2017-0084
29. Lin D, Li L, Xie T, et al (2018) Codon usage variation of Zika virus: The potential roles of NS2B and NS4A in its global pandemic. Virus Research 247:71–83. https://doi.org/10.1016/j.virusres.2018.01.014
30. Li Y, Deng X, Hu F, et al (2018) Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia. Journal of Infection 76:311–313. https://doi.org/10.1016/J.JINF.2017.10.012
31. Wang L, Jiao B, Lu J, et al (2017) A44 Determination of highly conserved sites by deep sequencing in avian influenza A virus H5N1. Virus Evolution 3:. https://doi.org/10.1093/ve/vew036.043
32. Pei N, Zhang J, Ma J, et al (2016) First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection. Virus Genes 52:620–624. https://doi.org/10.1007/s11262-016-1361-7
33. Ma J, Pallett D, Jiang H, et al (2015) Mutational bias of Turnip Yellow Mosaic Virus in the context of host anti-viral gene silencing. Virology 486:2–6
34. Wang Y, Wang H, Xu K, et al (2014) A survey of overlooked viral infections in biological experiment systems. PLoS ONE 9:
35. Wang H, Xie J, Shreeve TG, et al (2013) Sequence Recombination and Conservation of Varroa destructor Virus-1 and Deformed Wing Virus in Field Collected Honey Bees (Apis mellifera). PLoS ONE 8:
36. Fan C, Ma J, Guo Q, et al (2013) Selection of Reference Genes for Quantitative Real-Time PCR in Bamboo (Phyllostachys edulis). PLoS ONE 8:
专利：
1.测序获取寄生虫核酸信息及对寄生虫分类的方法和系统，2018102057021
2.基于外泌体DNA进行微生物检测的方法及其应用，201710254374.X
3.从样本中鉴定微生物物种的方法和装置，201710447898.0
4.鉴定病毒的方法和装置，201510125249X
5.用来评估艾滋病人发生免疫重建炎性综合症的标志物，CN201510542863
6.病历数据处理方法、装置以及系统，CN201510724624
7.构建鉴定感染性疾病和非感染性疾病的机器学习模型的方法，202210566863X
8.构建用于手足口样本归类的模型的方法及其应用，2020103131823
软著：
1.基于外周血游离核酸序列鉴定寄生虫流程软件，流水号：2017R11L1132183
2.流感病毒分析流程软件（IVAP），登记号：2012SR116193
3.人肠病毒分析流程（HEAP），流水号：2014R11L322913
