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刘洋

刘洋(liuyang9@genomics.cn)。利用单细胞多组学及时空组学平台研究模式物种及人类器官发育再生,衰老及演化。获得深圳市盐田区高层次人才-“梧桐人才”。获中国博士后科学基金72批资助。

研究方向:再生与衰老

现任岗位:华大研究院细胞所生物信息副研究员

教育背景:博士,基因组学,中国科学院大学

参与项目:

1.国家级、2022M722196、基于空间转录组技术研究脑重塑中神经胶质细胞的功能变化及调控机制,主持

2.国家级、31970573、单细胞测序技术揭示蚂蚁大脑神经可塑性,参与

3.国家级、2019YFE0106700、应用墨西哥钝口螈鉴定直接参与组织再生的细胞类型及其启动再生的关键因子,参与

4.人类全身皮肤全细胞图谱研究

5.损伤再生时空组学研究

论文:

1.Wei X, Fu S, Li H,Liu Y, et al. Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration[J]. Science, 2022, 377(6610): eabp9444.(co-first author/cover story)

2.Li Q, Wang M, Zhang P, Liu Y, et al. A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism[J]. Nature Ecology & Evolution, 2022, 6(8): 1191-1204. (co-first author/cover story)

3.Wang M, Liu Y, Wen T, et al. Chromatin accessibility and transcriptome landscapes of Monomorium pharaonis brain[J]. Scientific Data, 2020, 7(1): 217. (co-first author/cover story)

4.Han L, Wei X, Liu C, …Liu Y, et al. Cell transcriptomic atlas of the non-human primate Macaca fascicularis[J]. Nature, 2022, 604(7907): 723-731.

5.Chen A, Liao S, Cheng M,…Liu Y, et al. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays[J]. Cell, 2022, 185(10): 1777-1792. e21. (cover story)

6.Li H, Wei X, Zhou L, …Liu Y, et al. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis[J]. Protein & cell, 2021, 12(1): 57-66.

7.Liu L, Liu C, Quintero A, …Liu Y, et al. Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity[J]. Nature communications, 2019, 10(1): 470.

8.Zhu L, Yang P, Zhao Y,…Liu Y, et al. Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients[J]. Immunity, 2020, 53(3): 685-696. e3.

9.Wei X, Li H, Guo Y, …Liu Y, et al. An ATAC-seq dataset uncovers the regulatory landscape during axolotl limb regeneration[J]. Frontiers in Cell and Developmental Biology, 2021, 9: 651145.

10.Yu Y, Wei X, Deng Q, …Liu Y, et al. Single-nucleus chromatin accessibility landscape reveals diversity in regulatory regions across distinct adult rat cortex[J]. Frontiers in Molecular Neuroscience, 2021, 14: 651355.

11.Xu J, Hao S, Shi Q, …Liu Y, et al. Transcriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing[J]. Frontiers in Cell and Developmental Biology, 2022, 10: 833392.

12.Feng W, Liu S, Deng Q, …Liu Y, et al. A scATAC-seq atlas of chromatin accessibility in axolotl brain regions[J]. Scientific Data, 2023, 10(1): 627.

13.Yuan Y, Deng Q, Wei X, …Liu Y, et al. The Chromatin Accessibility Landscape of Adult Rat[J]. Frontiers in Genetics, 2021, 12: 651604.

14.He Y, Chang Y, Bao L, …Liu Y, et al. A chromosome‐level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth[J]. Molecular ecology resources, 2019, 19(5): 1309-1321.

专利:

1.一种外泌体微量DNA的建库方法

Research Gate 链接:

https://www.researchgate.net/profile/Yang-Liu-385

Google Scholar链接:

https://scholar.google.com.hk/citations?user=D0d56U8AAAAJ&hl=zh-CN






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