刘石平（liushiping@genomics.cn）。华大研究院超级细胞所，脑科学主任科学家，专注于生命科学大数据分析，单细胞和空间组学在脑科学中的应用和跨物种演化研究，研究肿瘤或其他免疫性相关疾病的机制等。
研究方向：生物信息学、基因组学、脑科学
现任岗位：华大研究院超级细胞所主任科学家
教育背景：华南理工大学遗传学博士
参与项目:
1.基于单细胞转录组的重大脑疾病分子靶点功能研究（主持）
2.肝癌肿瘤微环境中各类细胞间相互作用网络研究（主持）
3.基因编辑创制发育退行性与神经退行性疾病的猴模型及致病机制的研究(项目：发育、代谢复杂疾病灵长类动物模型的创制与临床前研究)
4.单细胞重点实验室（深圳市单细胞组学重点实验室）
5.糖脂等及其代谢中间物对关键组织器官发育和稳态的影响
论文:
Manuscripts:
1.Qiu X*, Zhu D*, Yao J*, …, Liu L#, Weissman J#, Liu S#, Bai Y#. Spateo: multidimensional spatiotemporal modeling of single-cell spatial transcriptomics. Cell (submitted, under reviewing). 2023（通讯）
2.Chen D, …, Liu S#. Single-cell atlas comparative analysis cross-species reveals the evolution of cell type reshaped by the gene family and gene positive selection in telencephalon and cerebellum of the amniotes. (Prepare to submit)（通讯）
3.Zhuang Z, …, Liu S#. Spatial transcriptome atlas reveals the convergent evolution of neocortex and DVR in amniotes. (Prepare to submit)（通讯）
Published:
4.Qin, Pengfei, Huaxian Chen, Yuhang Wang, Liang Wu, …, Shiping Liu#, Hongcheng Lin#. “Cancer-Associated Fibroblasts Undergoing Neoadjuvant Chemotherapy Suppress Rectal Cancer Revealed by Single-Cell and Spatial Transcriptomics.” Cell Reports Medicine 4, no. 10 (October 2023): 101231. https://doi.org/10.1016/j.xcrm.2023.101231. (通讯)
5.Liang Wu, Jiayan Yan, Yinqi Bai, Feiyu Chen, …, Shiping Liu#, …, Jian Zhou#. “An Invasive Zone in Human Liver Cancer Identified by Stereo-Seq Promotes Hepatocyte–Tumor Cell Crosstalk, Local Immunosuppression and Tumor Progression.” Cell Research, June 19, 2023. https://doi.org/10.1038/s41422-023-00831-1. (通讯)
6.Lei Y*, Cheng M*, Li Z*, …, Liu S#, Xu X#. Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex. Nat Commun. 2022;13(1):6747. doi:10.1038/s41467-022-34413-3 （通讯）
7.Wu L*, Jiang M, Wang Y, ..., Liu S#. scDPN for High-throughput Single-cell CNV Detection to Uncover Clonal Evolution During HCC Recurrence. Genomics Proteomics Bioinformatics. 2021;19. doi:10.1016/j.gpb.2021.03.008（通讯）
8.Sun Y-F*, Wu L*, Liu S-P*, Jiang M-M*, et al. Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma. Nat Commun. 2021;12(1):4091. doi:10.1038/s41467-021-24386-0 （第一）
9.Sun, Y.*, Wu, L.*#, Zhong, Y.*, Zhou, K.*, Hou, Y.*, Wang, Z., … Liu, S.#, Yang, X.#, Fan, J.# (2020). Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell, 1–18. （第一）
10.Wang, W.*, Zhong, Y.*, Zhuang, Z.*, Xie, J.*, Lu, Y.*, Huang, C.*, … Liu, S.#, Ling, F.#, Yao, X.# (2021). Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer. Clinical and Translational Medicine, 11(1). （通讯）
11.Natarajan, K. N.*, Miao, Z.*, Jiang, M.*, Huang, X.*, Zhou, H., Xie, J., … Shiping L.#, Teichmann, S. A.# (2019). Comparative analysis of sequencing technologies for single-cell transcriptomics. Genome Biology, 20(1), 70.（通讯）
12.Yu, Q.*, Zhang, W.*, Zhang, X.*, Zeng, Y., Wang, Y., Wang, Y., … ,Shiping Liu#, Li, B.# (2017). Population-wide sampling of retrotransposon insertion polymorphisms using deep sequencing and efficient detection. GigaScience, 6(9), 1–11.（通讯）
13.Zhao Z*, Goldin L*, Liu S*, Wu L*, Zhou W*, Lou H*, et al. Evolution of multiple cell clones over a 29-year period of a CLL patient. Nat Commun. 2016;7: 13765. doi:10.1038/ncomms13765（第一）
14.Liu, S.*, Lorenzen, E. D.*, Fumagalli, M.*, Li, B.*, Harris, K., Xiong, Z., … Wang, J.# (2014). Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. Cell, 157, 785–794. doi:10.1016/j.cell.2014.03.054（第一）
15.Jex, A. R.*, Liu, S.*, Li, B.*, Young, N. D.*, Hall, R. S., Li, Y., … Gasser, R. B. #(2011). Ascaris suum draft genome. Nature. doi:10.1038/nature10553（第一）
16.Dobrynin, P.*，Shiping Liu*, et al. Genomic legacy of the African cheetah, Acinonyx jubatus. Genome Biol. 16, 277 (2015). （第一）
Research Gate 链接:
https://www.researchgate.net/profile/Shiping-Liu-5
Google Scholar链接:
https://scholar.google.com.hk/citations?hl=en&user=W-S1wOUAAAAJ
