刘栋兵（liudongbing@genomics.cn）。自2010年加入华大基因，一直从事大规模癌症基因组测序数据分析和挖掘相关工作，先后负责与完成包括前列腺癌、食管癌、结直肠癌、肝癌和淋巴瘤等一系列癌症基因组研究攻关项目，同时参与国际癌症协作组（ICGC）发起的PCAWG和ARGO等大型国际癌症研究项目，目前已在《Nature》、《Cell Research》、《Nature Communications》等国际知名期刊累计发表论文26篇，其中一作或通讯8篇。此外，以项目带人才方式，建立了一支富有经验的癌症组学大数据研究团队，已累计完成联合培养学生12名（创新班9名，国科大3名）。
研究方向：癌症多组学大数据与精准医学应用
现任岗位：深圳华大基因股份有限公司-智惠医学研究院 专项科学家
教育背景：中山大学生物技术本科
参与项目:
1. 结直肠癌多组学研究（ICGC-ARGO项目）；
2. 淋巴瘤多组学研究；
3. 肝癌空间组学研究；
4. 肾癌空间组学研究；
论文:
1. Pecori R, Ren WC, Pirmoradian M, Binder M, Papavasiliou N, Wang XH, Liu DB, Berglund M, Li W, Tasakis RN et al: ADAR1-mediated RNA editing promotes B cell lymphomagenesis. Iscience 2023, 26(6).
2. Nie M, Ren WC, Ye XF, Berglund M, Wang XH, Fjorden K, Du LK, Giannoula Y, Lei DX, Su WJ et al: The dual role of CD70 in B-cell lymphomagenesis. Clin Transl Med 2022, 12(12).
3. Lin YP, Peng LH, Dong LQ, Liu DB, Ma JQ, Lin J, Chen XF, Lin PH, Song GH, Zhang M et al: Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma. Cancer Discov 2022, 12(10):2350-2371.
4. Xie FF, Ding D, Lin C, Cunningham D, Wright M, Javed AA, Azad N, Lee V, Donehower R, De Jesus-Acosta A et al: RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma. Jco Precis Oncol 2022, 6.
5. Ye XF, Maglione PJ, Wehr C, Li XB, Wang YT, Abolhassani H, Deripapa E, Liu DB, Borte S, Du LK et al: Genomic characterization of lymphomas in patients with inborn errors of immunity. Blood Adv 2022, 6(18):5403-5414.
6. Ren WC, Wang XH, Yang MY, Wan H, Li XB, Ye XF, Meng B, Li W, Yu JW, Lei MY et al: Distinct clinical and genetic features of hepatitis B virus-associated follicular lymphoma in Chinese patients. Blood Adv 2022, 6(9):2731-2744.
7. Nie M, Du L, Ren W, Joung J, Ye X, Shi X, Ciftci S, Liu D, Wu K, Zhang F et al: Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma. Cell Death Dis 2021, 12(5):419.
8. Ye X, Ren W, Liu D, Li X, Li W, Wang X, Meng FL, Yeap LS, Hou Y, Zhu S et al: Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas. J Exp Med 2021, 218(2).
9. Guallar D, Fuentes-Iglesias A, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Escudero A, Garcia-Outeiral V, Moreira T, Saenz C et al: ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress. Cell Stem Cell 2020, 27(2):300-314 e311.
10. Dong LQ, Peng LH, Ma LJ, Liu DB, Zhang S, Luo SZ, Rao JH, Zhu HW, Yang SX, Xi SJ et al: Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma. J Hepatol 2020, 72(5):896-908.
11. Group PTC, Calabrese C, Davidson NR, Demircioglu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y et al: Genomic basis for RNA alterations in cancer. Nature 2020, 578(7793):129-136.
12. Consortium ITP-CAoWG: Pan-cancer analysis of whole genomes. Nature 2020, 578(7793):82-93.
13. Hong S, Liu D, Luo S, Fang W, Zhan J, Fu S, Zhang Y, Wu X, Zhou H, Chen X et al: The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma. Nat Commun 2019, 10(1):3108.
14. Peng LH, Xing R, Liu DB, Bao L, Cheng WX, Wang HY, Yu Y, Liu XF, Jiang L, Wu Y et al: Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing. Sci Bull 2019, 64(4):236-244.
15. Wang F, Liu DB, Zhao Q, Chen G, Liu XM, Wang YN, Su H, Qin YR, He YF, Zou QF et al: The genomic landscape of small cell carcinoma of the esophagus. Cell Res 2018.
16. Ren W, Ye X, Su H, Li W, Liu D, Pirmoradian M, Wang X, Zhang B, Zhang Q, Chen L et al: Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma. Blood 2018.
17. Ren S, Wei GH, Liu D, Wang L, Hou Y, Zhu S, Peng L, Zhang Q, Cheng Y, Su H et al: Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression. Eur Urol 2017.
18. Xiong H, Liu D, Li Q, Lei M, Xu L, Wu L, Wang Z, Ren S, Li W, Xia M et al: RED-ML: a novel, effective RNA editing detection method based on machine learning. Gigascience 2017, 6(5):1-8.
19. Xing F, Luan Y, Cai J, Wu S, Mai J, Gu J, Zhang H, Li K, Lin Y, Xiao X et al: The Anti-Warburg Effect Elicited by the cAMP-PGC1alpha Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Rep 2017, 18(2):468-481.
20. Peng L, Lee LJ, Xiong H, Su H, Rao J, Xiao D, He J, Wu K, Liu D: Characterization of RNA editome in primary and metastatic lung adenocarcinomas. Oncotarget 2017, 8(7):11517-11529.
21. Qiu S, Li W, Xiong H, Liu D, Bai Y, Wu K, Zhang X, Yang H, Ma K, Hou Y et al: Single-cell RNA sequencing reveals dynamic changes in A-to-I RNA editome during early human embryogenesis. BMC Genomics 2016, 17(1):766.
22. Hansen SN, Ehlers NS, Zhu S, Thomsen MB, Nielsen RL, Liu D, Wang G, Hou Y, Zhang X, Xu X et al: The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells. BMC Genomics 2016, 17:442.
23. Fu R, Liu D, Cao Z, Zhu S, Li H, Su H, Zhang L, Xue F, Liu X, Zhang X et al: Distinct molecular abnormalities underlie unique clinical features of essential thrombocythemia in children. Leukemia 2016, 30(3):746-749.
24. Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, Liu D, Ye X, Ye M, Yang J et al: Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. Nat Commun 2015, 6:10131.
25. Jin M, Zhu S, Hu P, Liu D, Li Q, Li Z, Zhang X, Xie Y, Chen X: Genomic and epigenomic analyses of monozygotic twins discordant for congenital renal agenesis. Am J Kidney Dis 2014, 64(1):119-122.
26. Zhang F, Chen R, Liu D, Yao X, Li G, Jin Y, Yu C, Li Y, Coin LJ: YHap: a population model for probabilistic assignment of Y haplogroups from re-sequencing data. BMC Bioinformatics 2013, 14:331
