殷建华（yinjianhua@genomics.cn），深圳华大生命科学研究院副研究员，深圳市华大教育中心博士生导师，山西医科大学客座教授，河北医科大学硕士生导师。深圳市高层次人才，深圳市盐田区“梧桐凤凰”人才。长期致力于前沿生命组学技术在肿瘤免疫微环境、免疫疾病的发病机制等领域的研究和应用。发表SCI论文17篇，并以第一作者或通讯作者身份在Nature Medicine、Cancer Cell、Cell research 和The Innovation等国际知名学术期刊上发表代表性研究成果。
研究方向：基于单细胞测序的免疫相关疾病的机制研究，单细胞测序技术在疾病诊断中的应用研究及转化
现任岗位：深圳华大生命科学研究院副研究员
教育背景：北京协和医学院生物化学与分子生物学博士
研究摘要
1.基于单细胞测序的肿瘤免疫微环境研究,在这个领域我们利用单细胞测序技术深入分析了鼻咽癌、膀胱癌、胃癌和乳腺癌的免疫微环境特征(Chen et al., Cell Research 2020; Lv et al., Nature Medicine 2023; Ma et al., Cancer Cell 2022; Chen et al., J Transl Med 2022; Zhou et al., Clin Transl Med 2021)。2.基于单细胞多组学的健康和疾病人群的外周免疫特征研究(Yin et al., The Innovation 2022; Zhou et al., Communications Biology 2024)。我们最近结合单细胞多组学数据和基因组数据，研究细胞特异性和疾病特异性的基因表达调控，我们希望进一步阐明遗传和环境因素怎样通过互作调控人体在健康和疾病状态下的免疫功能。
论文
1.Jiawei Lv*, Yuan Wei*, Jian-Hua Yin*, Yu-Pei Chen*, Guan-Qun Zhou*, Chen Wei*, Xiao-Yu Liang*, Yuan Zhang*, Cui-Juan Zhang, Shi-Wei He, Qing-Mei He, Zhuo-Li Huang, Jia-Li Guan, Jia-Yi Shen, Xiao-Min Li, Jun-Yan Li, Wen-Fei Li, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Rui Sun, Yu-Hui Zheng, Wen-Wen Zhou, Ke-Xu Xiong, Si-Qi Wang, Xin Jin, Na Liu, Gui-Bo Li, Dong-Ming Kuang, Ying Sun, Jun Ma (2023). The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment. Nature Medicine. 29, 1424–1436. (并列第一作者)
2. Zikun Ma, Xiangdong Li, Yize Mao, Chen Wei, Zhuoli Huang, Guibo Li, Jianhua Yin*, Xiaoyu Liang*, Zhuowei Liu* (2022). Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer. Cancer Cell. 40, 1–16.(共同通讯作者)
3.Jianhua Yin, Yingze Zhao, Fubaoqian Huang, Yunkai Yang, Yaling Huang, Zhenkun Zhuang, Yanxia Wang et al. (2022). Immune response and homeostasis mechanism following administration of BBIBP-CorV SARS-CoV-2 inactivated vaccine. The Innovation. 100359, January 30, 2023
4.Yingtai Chen#, Jianhua Yin#, Lulu Zhao#, Guangyu Zhou#, Shichen Dong#, Yueming Zhang#, Penghui Niu#, Hu Ren#, Tianjiao Zheng, Juan Yan, Wenbin Li, Peiqin Ma, Cuijuan Zhang, Chen Wei, George Church, Guibo Li, Dongbing Zhao (2022). Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing. Journal of Translational Medicine. 20:563. (并列第一作者)
5.Jiajun Zhang*, Jianhua Yin*, Yang Heng, Ken Xie, Ao Chen, Ido Amit, Xiu-wu Bian, Xun Xu (2022). Spatiotemporal Omics-Refining the landscape of precision medicine. Life Medicine. 40, 1–16. (并列第一作者)
6. Hanlin Zhou*, Guibo Li*, Jianhua Yin*, Ting Wang*, Hong Hu*, Tong Li*, Qing Zhou, Jintao Hu, Lei Wang, Shichen Dong, Chen Wei, Cuijuan Zhang, Ye Lu, Wenbin Zhou, Chen Huang, Huanming Yang, Dongxian Zhou, Ling Wang, Kui Wu.(2021)Neoadjuvant chemotherapy alters peripheral and tumor-infiltrating immune cells in breast cancer revealed by single cell RNA sequencing. Clin Transl Med. 2021;11:e62 (并列第一作者)
7.Yu-Pei Chen*, Jian-Hua Yin*, Wen-Fei Li*, Han-Jie Li*, Dong-Ping Chen*, Cui-Juan Zhang*, Jia-Wei Lv, Ya-Qin Wang, Xiao-Min Li,Jun-Yan Li, Pan-Pan Zhang, Ying-Qin Li, Qing-Mei He, Xiao-Jing Yang, Yuan Lei, Ling-Long Tang, Guan-Qun Zhou,Yan-Ping Mao, Chen Wei, Ke-Xu Xiong, Hong-Bo Zhang, Shi-Da Zhu, Yong Hou, Ying Sun, Michael Dean , Ido Amit ,Kui Wu, Dong-Ming Kuang , Gui-Bo Li , Na Liu and Jun Ma. Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma. Cell Research (2020) 30:1024–1042 (并列第一作者)
8.Jianhua Yin, Zhifeng Wang, Guibo Li, Feng Lin, Kang Shao, Boyang Cao & Yong Hou. Characterization of circulating tumor cells in breast cancer patients by spiral microfluidics. Cell Biology and Toxicology volume 35, 59–66 (2019)
9.Jianhua Yin *, Yaling Huang *, Pengfei Guo, Siqi Hu, Sawako Yoshina, Nan Xuan, Qiwen Gan, Shohei Mitani, Chonglin Yang, and Xiaochen Wang (2017). GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. The Journal of Cell Biology. 216(6):1775-1794.
10.Wenwen Zhou*, Yixuan Chen*, Yuhui Zheng*, Yong Bai*, Jianhua Yin*, Xiao-Xia Wu, Mei Hong, Langchao Liang, Jing Zhang, Ya Gao, Ning Sun, Jiankang Li, Yiwei Zhang, Linlin Wu, Xin Jin, Jianmin Niu (2024). Characterizing immune variation and diagnostic indicators of preeclampsia by single-cell RNA sequencing and machine learning. Communications Biology. 7, 32.(并列第一作者)
